PLSCR1: A Drug Target / Disease Biomarker (G5359)

Target Name: PLSCR1

NCBI ID: G5359

PLSCR1: A Drug Target / Disease Biomarker

PLSCR1, also known as purine lactamase, is a protein that is expressed in various tissues throughout the body. It is a key enzyme in the purine biosynthesis pathway, which is the process by which the body builds and repairs DNA. PLSCR1 is highly conserved across different species, and its structure and function have been extensively studied.

PLSCR1 is a 26kDa protein that consists of 195 amino acid residues. It has a distinct N-terminus that is involved in protein-protein interactions and a C-terminus that is responsible for its catalytic activity. The protein is mostly localized to the cytoplasm of cells, but it can also be found in the nucleus and other organelles.

PLSCR1 functions as the catalytic unit of the purine biosynthesis pathway. It catalyzes the conversion of purine precursors to the final product, 5-uracil nucleotide. The enzyme uses its catalytic activity to convert guanine nucleotides (GNs) to their corresponding purine nucleotides. This reaction is critical for the growth and development of all living organisms, as it allows the cell to repair damaged DNA and maintain genetic integrity.

PLSCR1 is a key regulator of the purine biosynthesis pathway. It is well-known for its role in the regulation of gene expression and cell signaling. The enzyme has been shown to play a role in the regulation of cell proliferation, differentiation, and apoptosis.

PLSCR1 has also been shown to be involved in the regulation of DNA replication and repair. It has been shown to be essential for the proper functioning of the DNA replication machinery, as it helps to ensure that the genetic information in the cell is accurately copied.

In addition to its role in the regulation of DNA replication and repair, PLSCR1 has also been shown to be involved in the regulation of other cellular processes. For example, the enzyme has been shown to play a role in the regulation of cell adhesion, as it is involved in the formation of tight junctions between cells.

PLSCR1 has also been shown to be involved in the regulation of cellular signaling pathways. It has been shown to play a role in the regulation of cell signaling pathways, as it is involved in the signaling cascade that activates the protein kinase A (PKA).

In conclusion, PLSCR1 is a highly conserved protein that plays a critical role in the regulation of the purine biosynthesis pathway. Its function as a drug target or biomarker is significant, as it has been shown to be involved in the regulation of various cellular processes that are important for the survival and growth of cells. Further research is needed to fully understand the function of PLSCR1 and its potential as a drug target or biomarker.

Protein Name: Phospholipid Scramblase 1

Functions: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:9218461, PubMed:8663431, PubMed:10770950, PubMed:9572851, PubMed:9485382, PubMed:18629440, PubMed:23590222, PubMed:24648509, PubMed:24343571, PubMed:32110987, PubMed:23659204, PubMed:29748552). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (PubMed:27206388, PubMed:17567603). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724). May contribute to cytokine-regulated cell proliferation and differentiation (By similarity). May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes (PubMed:15308695). Acts as an attachment receptor for HCV (PubMed:21806988)

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