PLPP5 Regulates TGF-β and P53 Activities (G84513)

Target Name: PLPP5

NCBI ID: G84513

PLPP5 Regulates TGF-β and P53 Activities

PLPP5 (poly (L-伪-glutamyl) peptide-5) is a protein that is expressed in various tissues and cells in the human body. It is a key regulator of cellular processes, including cell signaling, DNA replication, and chromatin structure. PLPP5 has also been shown to play a role in the development and progression of various diseases, including cancer.

One of the key functions of PLPP5 is its ability to interact with other proteins, including the oncogene transforming growth factor (TGF-β). TGF-β is a well-known protein that plays a critical role in the development and maintenance of tissues, including muscles, bones, and organs. It is also involved in the regulation of cell signaling, including the regulation of cell proliferation and differentiation.

PLPP5 has been shown to regulate the activity of TGF-β by interacting with its extracellular domain. This interaction between PLPP5 and TGF-β has important implications for the regulation of cellular processes, including the regulation of cell signaling and the regulation of cell proliferation.

In addition to its role in regulating TGF-β activity, PLPP5 has also been shown to play a role in the regulation of other proteins, including the transcription factor p53. p53 is a well-known protein that is involved in the regulation of cellular processes, including cell growth, apoptosis (programmed cell death), and DNA repair.

PLPP5 has been shown to regulate the activity of p53 by interacting with its amino-terminal region. This interaction between PLPP5 and p53 has important implications for the regulation of cellular processes, including the regulation of cell growth, apoptosis, and DNA repair.

In conclusion, PLPP5 is a protein that has important implications for the regulation of cellular processes, including cell signaling, DNA replication, and chromatin structure. Its interaction with TGF-β and p53 suggests that PLPP5 plays a critical role in the regulation of cellular processes, including the regulation of cell growth, apoptosis, and DNA repair. Further research is needed to fully understand the role of PLPP5 in cellular processes and its potential as a drug target or biomarker.

Protein Name: Phospholipid Phosphatase 5

Functions: Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules (PubMed:17590538)

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