PLK3: A Potential Drug Target for Cellular Processes (G1263)

Target Name: PLK3

NCBI ID: G1263

PLK3: A Potential Drug Target for Cellular Processes

PLK3 (Polo-like kinase 3) is a protein that is expressed in various tissues throughout the body, including muscle, nerve, and heart cells. It is a key regulator of cell proliferation and has been implicated in a number of cellular processes, including cell survival, differentiation, and signaling.

PLK3 has been identified as a potential drug target due to its involvement in a number of diseases, including cancer, neurodegenerative diseases, and developmental disorders. Its role in these conditions has led to a growing interest in developing small molecule inhibitors of PLK3 as a new treatment option.

One of the key challenges in studying PLK3 is its complex structure and the various interactions between its different subunits. Despite its importance, PLK3 has not yet been fully understood, and much of its biology remains unexplored.

One of the key functions of PLK3 is its role in cell proliferation. PLK3 is involved in the G1/S transition, which is a critical step in the cell cycle where the cell prepares for cell division. During the G1/S transition, PLK3 helps to ensure that the cell stays in the G1 phase long enough to perform necessary preparation for cell division.

Additionally, PLK3 is involved in the regulation of cell survival. Studies have shown that PLK3 can promote the survival of cancer cells by regulating cell cycle progression and apoptosis. This may contribute to the development of cancer, as well as the progression of neurodegenerative diseases.

Another important function of PLK3 is its role in cell signaling. PLK3 is involved in a number of signaling pathways, including the TGF-β pathway and the PI3K/Akt pathway. These pathways are involved in a variety of cellular processes, including cell survival, differentiation, and signaling.

PLK3 is also involved in the regulation of cellular processes that are important for development and tissue repair. For example, PLK3 is involved in the regulation of cell migration, which is critical for the formation of tissues during development. Additionally, PLK3 is involved in the regulation of cell proliferation, which is important for tissue repair and regeneration.

In conclusion, PLK3 is a complex protein that plays a critical role in a variety of cellular processes. Its involvement in cell proliferation, survival, and signaling makes it an attractive target for small molecule inhibitors. Further research is needed to fully understand the role of PLK3 in disease and to develop new treatments based on its properties.

Protein Name: Polo Like Kinase 3

Functions: Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1

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