PLOD1: A Potential Drug Target and Biomarker (G5351)

Target Name: PLOD1

NCBI ID: G5351

PLOD1: A Potential Drug Target and Biomarker

Plasma cells, a type of white blood cell, play a crucial role in the immune response. They are responsible for producing antibodies, which are proteins that help to neutralize or destroy pathogens in the body. In individuals with multiple myeloma, a type of plasma cell cancer,PLOD1 (Profilerin Oligomeric Domain 1) has been identified as a potential drug target and biomarker.

PLOD1 is a protein that is expressed in the plasma cells of individuals with multiple myeloma. It is composed of four domains: a N-terminus, a transmembrane region, a cytoplasmic tail, and an C-terminus. The N-terminus of PLOD1 contains a conserved region that is involved in protein-protein interactions, while the transmembrane region is responsible for the internalization of the protein into the plasma cell membrane. The cytoplasmic tail of PLOD1 is involved in the stability and localization of the protein in the plasma cell.

Studies have shown that PLOD1 is involved in the regulation of several cellular processes, including cell growth, differentiation, and inflammation. It has been shown to play a role in the development and maintenance of plasma cells, as well as in the regulation of their functions.

One of the key functions of PLOD1 is its role in the regulation of the switch phase of B cell development. During this phase, PLOD1 is involved in the transition from a state of quiescence to an active state, where the cell is able to begin producing antibodies. This is a critical step in the development of a plasma cell, which is responsible for producing antibodies that help to neutralize or destroy pathogens in the body.

Another function of PLOD1 is its role in the regulation of inflammation. PLOD1 has been shown to be involved in the regulation of the activation and recruitment of immune cells, as well as in the regulation of their functions. This is important because it allows the immune system to respond effectively to an infection or inflammation in the body.

PLOD1 has also been shown to play a role in the regulation of cell survival. Studies have shown that PLOD1 is involved in the regulation of cell survival by preventing the clearance of damaged or dysfunctional cells. This is important because it allows the body to maintain a healthy balance of cells, which is essential for overall health and functioning.

In conclusion, PLOD1 is a protein that is expressed in the plasma cells of individuals with multiple myeloma. It is involved in several cellular processes, including the regulation of cell growth, differentiation, and inflammation. Studies have also shown that PLOD1 is involved in the regulation of the switch phase of B cell development and the regulation of cell survival. These functions make PLOD1 a potential drug target and biomarker for the treatment of multiple myeloma. Further research is needed to fully understand the role of PLOD1 in the development and treatment of this disease.

Protein Name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

Functions: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:8621606, PubMed:10686424, PubMed:15854030). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable)

More Common Targets