PLEKHA2: A Potential Drug Target and Biomarker (G59339)

Target Name: PLEKHA2

NCBI ID: G59339

PLEKHA2: A Potential Drug Target and Biomarker

Plekha2 (PH domain-containing family A member 2) is a protein that is expressed in various tissues of the human body. It is a member of the PH domain-containing family A, which is a group of proteins that contain a characteristic PH domain. The PH domain is a structural region that is composed of a hydrophobic core and a hydrophilic tail that is able to interact with various ligands, including small molecules, ions, and proteins.

Plekha2 has been shown to play a role in various physiological processes in the body, including cell signaling, tissue repair, and inflammation. It is also expressed in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

As a drug target, Plekha2 is a potential target for small molecules that are able to modulate its activity. One such drug is a small molecule called 2-[(2-methylpropyl)amino]-2-propanethiol (2-MPA), which is a derivative of the amino acid leucine. 2-MPA has been shown to interact with Plekha2 and modulate its activity.

In addition to its potential as a drug target, Plekha2 is also a potential biomarker for various diseases. Its expression has been shown to be elevated in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. This suggests that Plekha2 may be a useful biomarker for these diseases, and that its levels may be able to be used as a diagnostic marker.

Furthermore, Plekha2 has also been shown to play a role in the regulation of cellular processes, including cell signaling, cell division, and cell migration. Its expression has been shown to be regulated by various factors, including cytokines, growth factors, and stress hormones. This suggests that Plekha2 may be a useful target for drugs that are able to modulate its activity and improve cellular processes.

In conclusion, Plekha2 is a protein that is expressed in various tissues of the human body and has been shown to play a role in various physiological processes. Its expression has also been associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. As a drug target and biomarker, Plekha2 is a promising target for small molecules that are able to modulate its activity. Further research is needed to fully understand its role in these processes and to develop effective treatments.

Protein Name: Pleckstrin Homology Domain Containing A2

Functions: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity)

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