Pleckha7: A Protein with Potential as A Drug Target and Biomarker

Target Name: PLEKHA7

NCBI ID: G144100

Pleckha7: A Protein with Potential as A Drug Target and Biomarker

Pleckha7, also known as A7, is a protein that is located in the endoplasmic reticulum (ER) and plays a critical role in the regulation of protein stability and localization. It is made up of a domain containing homology with the protein pleckstrin, which is also known as A2. The pleckstrin domain is a small protein that is found in a variety of organisms and functions as a binding protein for various intracellular molecules.

One of the key functions of Pleckha7 is its role in the regulation of protein stability. It is known to interact with several different protein substrates and has been shown to play a role in the stability of a variety of proteins, including the protein tyrosine phosphatase (PTP) and the protein serine/thiosephosphate kinase (STK).

In addition to its role in protein stability, Pleckha7 is also involved in the regulation of protein localization. It has been shown to interact with the proteinBeclin-1 (BECN1), which is a protein that is involved in the regulation of cell adhesion. This interaction between Pleckha7 and Beclin-1 has been shown to play a role in the regulation of protein localization and stability.

Pleckha7 is also of interest as a potential drug target. Its role in the regulation of protein stability and localization makes it a potential target for small molecules that can modulate its activity. For example, drugs that inhibit the interaction between Pleckha7 and Beclin-1 may have therapeutic benefits in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Another potential application of Pleckha7 is as a biomarker. Its role in the regulation of protein stability and localization makes it a potential indicator of the health of cells. For example, decreased levels of Pleckha7 have been shown to be associated with the development of a variety of diseases, including cancer and neurodegenerative disorders.

In conclusion, Pleckha7 is a protein that is of interest as a potential drug target and biomarker. Its role in the regulation of protein stability and localization makes it a potential target for small molecules that can modulate its activity. Further research is needed to fully understand the role of Pleckha7 in the regulation of protein stability and localization, as well as its potential as a drug target and biomarker.

Protein Name: Pleckstrin Homology Domain Containing A7

Functions: Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011)

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