PLEKHH3: A Potential Drug Target and Biomarker (G79990)

Target Name: PLEKHH3

NCBI ID: G79990

Other Name(s): pleckstrin homology domain-containing family H member 3 | PH domain-containing family H member 3 | PLEKHH3 variant 1 | Pleckstrin homology, MyTH4 and FERM domain containing H3, transcript variant 1 | pleckstrin homology, MyTH4 and FERM domain containing H3 | Pleckstrin homology domain-containing family H member 3 | Pleckstrin homology domain-containing family H member 3 precursor | PKHH3_HUMAN | pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

PLEKHH3: A Potential Drug Target and Biomarker

Pleckstrin homology (PH) domains are a family of transmembrane proteins that play a crucial role in various cellular processes. One of the PH domains is PLEKHH3, which is a member of the H-type PH domain family. PLEKHH3 is highly conserved and has been identified in various organisms, including bacteria, archaea, and eukaryotes. It is characterized by a characteristic PH domain sequence and is involved in various cellular processes, including DNA replication, transcription, and cell signaling.

Pleckstrin homology domains are small conserved regions that are commonly found in proteins that have a role in various cellular processes. They are characterized by a characteristic sequence that is composed of three or four amino acids that is similar to the PH domain sequence found in other proteins. The PH domain is a conserved region that is involved in the formation of a trimeric complex with the N-terminal domain of the protein and the C-terminal domain of a smaller protein. This trimeric complex is thought to play a role in the regulation of various cellular processes, including DNA replication, transcription, and signaling.

PLEKHH3 is a member of the H-type PH domain family, which is characterized by the presence of the conserved sequence Asp-221 and Asn-222 in the PH domain. This family of proteins is involved in the regulation of various cellular processes, including DNA replication, transcription, and signaling. PLEKHH3 is highly conserved and has been identified in various organisms, including bacteria, archaea, and eukaryotes. It is characterized by a characteristic PH domain sequence and is involved in various cellular processes, including DNA replication, transcription, and cell signaling.

Pleckstrin homology domains are involved in various cellular processes and have been identified as potential drug targets. PLEKHH3 is a potential drug target due to its involvement in the regulation of DNA replication and transcription. It has been shown to play a role in the regulation of DNA replication in various organisms, including bacteria and archaea. Additionally, PLEKHH3 has also been shown to play a role in the regulation of transcription in various organisms.

PLEKHH3 has also been identified as a potential biomarker for various diseases. The regulation of DNA replication and transcription is involved in the development and progression of various diseases, including cancer. Therefore, PLEKHH3 has been suggested as a potential biomarker for cancer. Additionally, the regulation of DNA replication and transcription is also involved in the treatment of various diseases, including cancer. Therefore, PLEKHH3 has also been suggested as a potential drug target for cancer treatment.

In conclusion, PLEKHH3 is a highly conserved PH domain protein that is involved in various cellular processes, including DNA replication, transcription, and cell signaling. It is a potential drug target and biomarker for various diseases, including cancer. Further research is needed to fully understand the role of PLEKHH3 in cellular processes and its potential as a drug target and biomarker.

Protein Name: Pleckstrin Homology, MyTH4 And FERM Domain Containing H3

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