PLEKHA3: A Potential Drug Target for Neurodegenerative Diseases

Target Name: PLEKHA3

NCBI ID: G65977

Other Name(s): PKHA3_HUMAN | pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 | Phosphoinositol 4-phosphate adapter protein 1 | pleckstrin homology domain containing A3 | Pleckstrin homology domain-containing family A member 3 | FAPP-1 | four-phosphate-adaptor protein 1 | Pleckstrin homology domain containing A3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | Phosphatidylinositol-four-phosphate adapter protein 1 | PH domain-containing family A member 3 | pleckstrin homology domain-containing family A member 3 | phosphoinositol 4-phosphate adapter protein 1 | phosphatidylinositol-four-phosphate adapter protein 1 | FAPP1

PLEKHA3: A Potential Drug Target for Neurodegenerative Diseases

PLEKHA3 (PKHA3_HUMAN) is a gene that encodes a protein known as phosphorylated-leucine-rich repeat-containing protein 3 (PLRCCP3). The PLRCCP3 protein is a non-protein kinase B (NPKB) regulatory protein that is involved in a variety of cellular processes, including cell signaling, DNA replication, and stress response.

PLRCCP3 is highly conserved across various species, including humans, and has been identified as a potential drug target in the field of neurodegenerative diseases. The neurodegenerative diseases that PLEKHA3 is associated with include Alzheimer's disease, Parkinson's disease, and Huntington's disease.

The exact mechanism by which PLEKHA3 contributes to the development and progression of neurodegenerative diseases is not yet fully understood. However, research has shown that PLEKHA3 plays a role in the regulation of cellular stress responses, which are critical for maintaining the integrity of cellular homeostasis.

In neurodegenerative diseases, cellular stress responses are often disrupted, leading to the accumulation of cellular stress-induced misfolded proteins, including beta-amyloid peptides and tau tangles, which are thought to contribute to the development and progression of these diseases.

PLEKHA3 is known to play a role in the regulation of the stress response by affecting the activity of several key cellular signaling pathways, including the TOR signaling pathway, the PI3K/Akt signaling pathway, and the p53 signaling pathway.

In addition to its role in stress response, PLEKHA3 is also involved in the regulation of cell signaling and DNA replication. Specifically, PLEKHA3 has been shown to play a role in the regulation of the growth and differentiation of neural stem cells, and it has been shown to interact with several key transcription factors, including Sox2 and NF1.

Furthermore, PLEKHA3 is also involved in the regulation of cell adhesion and migration. Specifically, PLEKHA3 has been shown to play a role in the regulation of tight junction formation and cell-cell adhesion, and it has been shown to interact with several key cell adhesion molecules, including E-cadherin.

In conclusion, PLEKHA3 is a gene that is involved in a variety of cellular processes that are critical for maintaining cellular homeostasis. The disruption of these processes is thought to contribute to the development and progression of neurodegenerative diseases. Therefore, PLEKHA3 is an attractive drug target for the development of new treatments for these diseases.

Protein Name: Pleckstrin Homology Domain Containing A3

Functions: Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099)

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