PLD1: A Drug Target / Disease Biomarker (G5337)

Target Name: PLD1

NCBI ID: G5337

PLD1: A Drug Target / Disease Biomarker

PLD1 (Proteasome-Lysine Derivative), also known as P120, is a protein that is expressed in various tissues and cells throughout the body. It plays a crucial role in the regulation of protein degradation and has been implicated in a number of cellular processes, including cell signaling, inflammation, and stress resistance.

One of the key functions of PLD1 is its role in the degradation of intracellular proteins, which are proteins that are synthesized but not translated into functional proteins. This process is known as protein degradation and is critical for maintaining the stability and integrity of cellular proteins. PLD1 is also involved in the regulation of protein synthesis, particularly in the context of stress and cellular signaling pathways.

In addition to its role in protein degradation, PLD1 has also been shown to play a number of different roles in cellular signaling pathways. For example, PLD1 has been shown to play a role in the regulation of cell signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a key pathway in the development and maintenance of tissues and organs.

PLD1 has also been shown to play a role in the regulation of inflammation and immune responses. For example, PLD1 has been shown to be involved in the regulation of the production of pro-inflammatory cytokines, such as TNF-伪 and IL-12. These cytokines play important roles in the regulation of immune responses and are involved in the development of a range of diseases, including cardiovascular disease and autoimmune disorders.

In addition to its role in cellular signaling and immune responses, PLD1 has also been shown to play a role in the regulation of cell cycle progression. This is the process by which cells grow, divide, and replicate their genetic material. PLD1 is involved in the regulation of the G1 phase of the cell cycle, which is the stage of cell growth and preparation for cell division.

PLD1 has also been shown to play a role in the regulation of DNA replication and repair. This is the process by which a cell replicates its genetic material and ensures the continuation of its genetic heritage. PLD1 is involved in the regulation of DNA replication and repair, including the repair of DNA damage caused by exposure to radiation or other forms of stress.

In conclusion, PLD1 is a protein that plays a critical role in a number of cellular processes that are important for the maintenance of cellular stability and homeostasis. Its involvement in the regulation of protein degradation, signaling pathways, inflammation, immune responses, cell cycle progression, and DNA replication and repair make it an attractive target for drug development. Further research is needed to fully understand the full range of functions of PLD1 and to develop effective therapies that target this protein.

Protein Name: Phospholipase D1

Functions: Function as phospholipase selective for phosphatidylcholine (PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity)

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