PLAC8: A Protein Involved in Cell Signaling and Apoptosis (G51316)

Target Name: PLAC8

NCBI ID: G51316

PLAC8: A Protein Involved in Cell Signaling and Apoptosis

PLAC8 (Onzin) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and liver. It is a member of the oncogene PIK3CA family, which encodes proteins that are involved in cell signaling pathways. PLAC8 is unique among the PIK3CA family members because it is able to interact with the protein p21, which is a negative regulator of the T-cell receptor signaling pathway. This interaction between PLAC8 and p21 has important implications for the regulation of cell proliferation and survival.

One of the functions of PLAC8 is to regulate the activity of the T-cell receptor, which is a protein that is involved in the development and activation of T-cells. T-cells are a type of white blood cell that play a critical role in the immune system, and they are able to recognize and respond to the presence of foreign substances in the body. The T-cell receptor is involved in the signaling pathway that regulates the activation and proliferation of T-cells, and PLAC8 is able to interact with it to regulate its activity.

PLAC8 is also involved in the regulation of cell apoptosis, which is the process by which cells die and are removed from the body. During apoptosis, PLAC8 is able to interact with the protein Bcl-2, which is a protein that is involved in the regulation of cell death. This interaction between PLAC8 and Bcl-2 allows PLAC8 to regulate the activity of Bcl-2 and influence the decision of cells to undergo apoptosis.

In addition to its role in regulating T-cell receptor signaling and apoptosis, PLAC8 is also involved in the regulation of cell adhesion. Adhesion is the process by which cells stick together and form tissues. PLAC8 is able to interact with the protein Focal Adhesion Protein (FAP), which is involved in the regulation of cell adhesion. This interaction between PLAC8 and FAP allows PLAC8 to regulate the activity of FAP and influence the formation of tissues.

PLAC8 is also involved in the regulation of cell migration. Migration is the process by which cells move from one location to another in the body. PLAC8 is able to interact with the protein vimentin, which is involved in the regulation of cell migration. This interaction between PLAC8 and vimentin allows PLAC8 to regulate the activity of vimentin and influence the migration of cells.

In conclusion, PLAC8 is a protein that is involved in the regulation of various cellular processes in the body. Its unique ability to interact with the protein p21 and the T-cell receptor has important implications for the regulation of cell proliferation and survival. Furthermore, PLAC8's involvement in the regulation of cell adhesion and migration adds to its role in the regulation of cellular processes. PLAC8 is a potential drug target and may be a biomarker for various diseases.

Protein Name: Placenta Associated 8

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