Group IIF Secretory Phospholipase A2: Potential Drug Targets (G64600)

Target Name: PLA2G2F

NCBI ID: G64600

Group IIF Secretory Phospholipase A2: Potential Drug Targets

PLA2G2F, also known as Group IIF secretory phospholipase A2 (isoform 1), is a protein that is expressed in various cell types throughout the body. It is a potent enzyme that is involved in the process of phospholipase A2, which is the breakdown of phospholipid molecules that form the membrane of all cells.

PLA2G2F is a member of the A2 family of phospholipase enzymes, which are known for their ability to catalyze the hydrolysis of fatty acids. These enzymes are involved in the production of various signaling molecules, including phosphatidyl choline, which is a key component of cell membranes.

PLA2G2F is also involved in the production of other signaling molecules, including inositol and ceramide. These molecules are important for various cellular processes, including cell signaling, inflammation, and stress resistance.

One of the key functions of PLA2G2F is its role in cell signaling. PLA2G2F is involved in the production of various signaling molecules, including inositol, which is a key signaling molecule that regulates various cellular processes. In addition, PLA2G2F is also involved in the production of ceramide, which is a potent anti-inflammatory molecule.

PLA2G2F is also involved in the regulation of cellular processes that are critical for cell survival. For example, PLA2G2F is involved in the production of phosphatidylcholine, which is a key component of cell membranes. Without this molecule, cells would not be able to maintain their normal structure and function.

In addition to its role in cell signaling and cell survival, PLA2G2F is also involved in the regulation of inflammation. For example, PLA2G2F is involved in the production of pro-inflammatory molecules, such as caspase-1 and iNOS. These molecules are important for the recruitment of immune cells to sites of inflammation, and for the production of pro-inflammatory cytokines.

PLA2G2F is also involved in the regulation of cellular processes that are critical for embryonic development and tissue repair. For example, PLA2G2F is involved in the production of a variety of signaling molecules that are important for neural tube development and retinal formation.

In conclusion, PLA2G2F is a protein that is involved in a variety of cellular processes that are critical for cell survival and development. As a result, PLA2G2F is a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of PLA2G2F in cellular processes and its potential as a therapeutic agent.

Protein Name: Phospholipase A2 Group IIF

Functions: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines (PubMed:11112443). May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity)

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