PJVK-HUMAN: A Potential Drug Target and Biomarker (G494513)

Target Name: PJVK

NCBI ID: G494513

PJVK-HUMAN: A Potential Drug Target and Biomarker

PJVK-HUMAN (Peroxisomein-Like Protein 2) is a protein that is expressed in various tissues of the human body, including the brain, heart, liver, and kidneys. It is a member of the peroxisomein gene family, which is known for the involvement of various cellular processes, including energy metabolism and stress responses. PJVK-HUMAN has been identified as a potential drug target and biomarker due to its unique structure, expression pattern, and function in the human body.

The Peroxisomein Gene Family

Peroxisomein (PJVK) is a peroxisomein gene that encodes a protein that is involved in various cellular processes. The PJVK gene is located on chromosome 11q22 and has four exons. PJVK-HUMAN is a variant of the PJVK gene that has been expressed in various tissues of the human body.

The peroxisomein gene family is characterized by the presence of a unique C-terminal region that is involved in the formation of peroxisomes. Peroxisomes are organelles that are involved in the production of reactive oxygen species (ROS), which can cause damage to cellular components and contribute to various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

Expression Pattern of PJVK-HUMAN

PJVK-HUMAN is expressed in various tissues of the human body, including the brain, heart, liver, and kidneys. It is found in the peroxisome, which is a organelle that is involved in the production of ROS. PJVK-HUMAN is also expressed in the endoplasmic reticulum (ER), which is the part of the cell that responsible for the production and delivery of proteins.

Function of PJVK-HUMAN

PJVK-HUMAN is involved in various cellular processes, including energy metabolism and stress responses. It is a key regulator of the peroxisome and is involved in the production of ROS. ROS can cause damage to cellular components and contribute to various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

PJVK-HUMAN has been shown to play a role in the regulation of cellular processes that are important for brain function, such as cell survival and neurogenesis. It has also been shown to play a role in the regulation of energy metabolism, including the production of ATP.

Potential Drug Target and Biomarker

PJVK-HUMAN is a potential drug target due to its unique structure, expression pattern, and function in the human body. The peroxisomein gene family is known for the involvement of various cellular processes, including energy metabolism and stress responses. As a result, PJVK-HUMAN may be a good candidate for drugs that are designed to modulate these cellular processes and prevent the development of various diseases.

In addition to its potential as a drug target, PJVK-HUMAN has also been identified as a biomarker. The PJVK-HUMAN protein can be used as a marker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. This protein has been shown to be expressed in various tissues of the human body, including the brain, heart, liver, and kidneys, which makes it a potential biomarker for these diseases.

Conclusion

PJVK-HUMAN is a protein that is expressed in various tissues of the human body and is involved in various cellular processes, including energy metabolism and stress responses. Its unique structure, expression pattern, and function make it a potential drug target and biomarker. Further research is needed to fully understand the role of PJVK-HUMAN in the human body and its potential as a drug

Protein Name: Pejvakin

Functions: Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation

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