PIP4K2B: Key Enzyme in Fc-RI Pathway (G8396)

Target Name: PIP4K2B

NCBI ID: G8396

PIP4K2B: Key Enzyme in Fc-RI Pathway

PIP4K2B (4-phosphatidylinositol 4-kinase 2B) is a protein that is expressed in various tissues and cells in the human body. It plays a crucial role in the intracellular signaling pathway known as the PI3K/AKT signaling pathway. This pathway is involved in various cellular processes, including cell survival, metabolism, and inflammation. PIP4K2B is a key enzyme in this pathway and is involved in the regulation of various signaling pathways, including the Fc-RI (fucose-induced insulin secretion) pathway.

The Fc-RI pathway is a well-established insulin secretion pathway that is involved in the regulation of glucose levels in the body. Insulin is a hormone that plays a critical role in regulating blood sugar levels and is produced by the pancreas. However, in individuals with diabetes, the body is less able to produce or respond to insulin, leading to high levels of blood sugar. The Fc-RI pathway is a critical pathway that regulates insulin secretion in response to changes in glucose levels.

PIP4K2B is a key enzyme in the Fc-RI pathway. It is a protein that is involved in the regulation of various signaling pathways, including the PI3K/AKT signaling pathway. This pathway is involved in the regulation of various cellular processes, including cell survival, metabolism, and inflammation. PIP4K2B is a key enzyme in this pathway and is involved in the regulation of various signaling pathways, including the Fc-RI pathway.

The PI3K/AKT signaling pathway is a well-established signaling pathway that is involved in the regulation of various cellular processes. It is a protein that is involved in the regulation of various signaling pathways, including the Fc-RI pathway. PIP4K2B is a key enzyme in this pathway and is involved in the regulation of insulin secretion in response to changes in glucose levels.

PIP4K2B is a protein that is expressed in various tissues and cells in the human body. It plays a crucial role in the intracellular signaling pathway known as the PI3K/AKT signaling pathway. This pathway is involved in various cellular processes, including cell survival, metabolism, and inflammation. PIP4K2B is a key enzyme in this pathway and is involved in the regulation of various signaling pathways, including the Fc-RI pathway.

The Fc-RI pathway is a critical pathway that regulates insulin secretion in response to changes in glucose levels. PIP4K2B is a key enzyme in this pathway and is involved in the regulation of insulin secretion in response to changes in glucose levels.

PIP4K2B is a protein that is involved in the regulation of various signaling pathways, including the PI3K/AKT and Fc-RI pathways. It is a key enzyme in the Fc-RI pathway and is involved in the regulation of insulin secretion in response to changes in glucose levels.

PIP4K2B is a protein that is expressed in various tissues and cells in the human body. It plays a crucial role in the intracellular signaling pathway known as the PI3K/AKT signaling pathway. This pathway is involved in various cellular processes, including cell survival, metabolism, and inflammation. PIP4K2B is a key enzyme in this pathway and is involved in the regulation of various signaling pathways, including the Fc-RI pathway.

The Fc-RI pathway is a critical pathway that regulates insulin secretion in response to changes in glucose levels. PIP4K2B is a key enzyme in this pathway and is involved in the regulation of insulin secretion in response to changes in glucose levels.

PIP4K2B is a protein that is involved in the regulation of various signaling pathways, including the PI3K/AKT and Fc-RI pathways. It is a key enzyme in the Fc-RI pathway and is involved in the regulation of insulin secretion in response to changes in glucose levels.

PIP4K2B is a protein that is expressed in various tissues and cells in the human body. It plays a crucial role in the intracellular signaling pathway known as the PI3K/AKT signaling pathway. This pathway is involved in various cellular processes, including cell survival, metabolism, and inflammation. PIP4K2B is a key enzyme in this pathway

Protein Name: Phosphatidylinositol-5-phosphate 4-kinase Type 2 Beta

Functions: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:9038203, PubMed:26774281). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439)

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