Target Name: PI3
NCBI ID: G5266
Other Name(s): Peptidase inhibitor 3 | skin-derived antileukoproteinase | peptidase inhibitor 3, skin-derived | ELAF_HUMAN | peptidase inhibitor 3 | pre-elafin | Protease inhibitor 3, skin-derived (SKALP) | WAP four-disulfide core domain protein 14 | Skin-derived antileukoproteinase | elastase-specific inhibitor | MGC13613 | Elafin | WAP3 | PI-3 | WFDC14 | Protease inhibitor WAP3 | protease inhibitor WAP3 | trappin-2 | ESI | cementoin | WAP four-disulfide core domain 14 | Elastase-specific inhibitor | SKALP | protease inhibitor 3, skin-derived (SKALP)

PI3: A Promising Drug Target and Biomarker for the Treatment of Inflammatory Diseases

Introduction

Inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, and chronic obstructive pulmonary disease (COPD), cause significant morbidity and mortality worldwide. Chronic inflammation in these diseases can lead to progressive tissue damage, chronic pain, and a decreased quality of life. The identification of potential drug targets and biomarkers has the potential to treat these diseases more effectively. One such drug target is PI3, a peptidase inhibitor that has been shown to have anti-inflammatory properties in various experimental models.

PI3: A naughty element

PI3 is a small molecule that can inhibit the activity of peptidases, which are enzymes that break down other proteins into smaller peptides. Peptidases are involved in many cellular processes, including inflammation, tissue repair, and neurotransmission. In diseases where inflammation is involved, such as inflammatory bowel disease and rheumatoid arthritis, peptidases can contribute to the destruction of tissue and the production of harmful autoantibodies. By inhibiting peptidases, PI3 has been shown to have anti-inflammatory effects and may be a promising drug target or biomarker for the treatment of inflammatory diseases.

Identification as a potential drug target

The identification of PI3 as a potential drug target is based on several factors. First, PI3 has been shown to have anti-inflammatory effects in various experimental models, including mouse models of rheumatoid arthritis and human samples with inflammatory bowel disease. Second, PI3 has been shown to inhibit the activity of peptidases, including the well-known enzyme trypsin, which is involved in the production of inflammatory cytokines. Third, PI3 has been shown to promote the production of anti-inflammatory cytokines, such as IL-10, in mouse models of inflammatory diseases.

Bioavailability and safety

While PI3 has shown promise in clinical trials, further studies are needed to determine its safety and bioavailability. Currently, PI3 is available as a highly potent inhibitor of trypsin and can be administered to animals or human volunteers in a laboratory setting. The safety of PI3 in humans has not been fully evaluated, and further studies are needed to determine its safety and efficacy in clinical trials.

Conclusion

PI3 is a small molecule that has been shown to have anti-inflammatory effects in various experimental models. Its potential as a drug target or biomarker for the treatment of inflammatory diseases is being investigated in clinical trials. Further studies are needed to determine its safety and bioavailability, and if it can be an effective treatment for inflammatory diseases. PI3 may be a promising target for the development of new anti-inflammatory drugs that can improve the quality of life for people with chronic inflammatory diseases.

Protein Name: Peptidase Inhibitor 3

Functions: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648)

More Common Targets

PI4K2A | PI4K2B | PI4KA | PI4KAP1 | PI4KAP2 | PI4KB | PIANP | PIAS1 | PIAS2 | PIAS3 | PIAS4 | PIBF1 | PICALM | PICART1 | PICK1 | PICSAR | PID1 | PIDD1 | PIERCE1 | PIERCE2 | PIEZO1 | PIEZO2 | PIF1 | PIFO | PIGA | PIGB | PIGBOS1 | PIGC | PIGF | PIGG | PIGH | PIGK | PIGL | PIGM | PIGN | PIGO | PIGP | PIGQ | PIGR | PIGS | PIGT | PIGU | PIGV | PIGW | PIGX | PIGY | PIGZ | PIH1D1 | PIH1D2 | PIK3AP1 | PIK3C2A | PIK3C2B | PIK3C2G | PIK3C3 | PIK3CA | PIK3CA-DT | PIK3CB | PIK3CD | PIK3CD-AS1 | PIK3CD-AS2 | PIK3CG | PIK3IP1 | PIK3IP1-DT | PIK3R1 | PIK3R2 | PIK3R3 | PIK3R4 | PIK3R5 | PIK3R6 | PIKFYVE | PILRA | PILRB | Pim Kinase | PIM1 | PIM2 | PIM3 | PIMREG | PIN1 | PIN1-DT | PIN1P1 | PIN4 | PINCR | PINK1 | PINK1-AS | PINLYP | PINX1 | PIP | PIP4K2A | PIP4K2B | PIP4K2C | PIP4P1 | PIP4P2 | PIP5K1A | PIP5K1B | PIP5K1C | PIP5K1P1 | PIP5KL1 | PIPOX | PIPSL | PIR