PICART1: A Potential Drug Target for Cancer (G284080)

Target Name: PICART1

NCBI ID: G284080

Other Name(s): P53 inducible cancer associated RNA transcript 1 | p53 inducible cancer associated RNA transcript 1

PICART1: A Potential Drug Target for Cancer

PICART1, also known as P53 inducible cancer associated RNA transcript 1, is a gene that has been identified as a potential drug target or biomarker for cancer. The PICART1 gene is located on chromosome 18 and encodes a 24.5 kilobase (kb) RNA molecule. PICART1 is highly expressed in various types of cancer, including breast, ovarian, and colorectal cancer. The gene has been shown to be involved in cell proliferation, apoptosis, and angiogenesis, which are important processes in cancer development and progression.

Drug Target Potential

PICART1 has been identified as a potential drug target due to its involvement in cell signaling pathways that are commonly disrupted in cancer. One of the key signaling pathways that PICART1 is involved in is the TGF-灏? pathway. This pathway is known to play a role in cell proliferation, differentiation, and survival, and is often disrupted in cancer cells.

PICART1 has been shown to be a positive regulator of the TGF-灏? pathway, which means that it increases the activity of the TGF-灏? receptor. This increase in TGF-灏? activity can lead to increased cell proliferation and survival, which are hallmarks of cancer growth and progression.

In addition to its role in the TGF-灏? pathway, PICART1 has also been shown to be involved in the FGF signaling pathway. The FGF pathway is known to play a role in cell proliferation and survival, and is often disrupted in cancer cells. PICART1 has been shown to regulate the activity of the FGF receptor, which is a protein that binds to the FGF protein.

Biomarker Potential

PICART1 has also been identified as a potential biomarker for cancer due to its increased expression in cancer cells. The increased expression of PICART1 has been shown to be associated with cancer-specific survival in various types of cancer. In addition, the expression of PICART1 has been shown to be associated with the severity of cancer-specific symptoms, such as pain, fatigue, and nausea.

PICART1 has also been shown to be involved in the production of pro-inflammatory cytokines, such as TNF-浼? and IL-8. These cytokines have been shown to play a role in cancer immune surveillance and have been shown to contribute to the development of cancer-specific immune evasion.

Conclusion

PICART1 is a gene that has been identified as a potential drug target or biomarker for cancer. Its involvement in the TGF-灏? and FGF signaling pathways, as well as its potential role as a biomarker for cancer, makes it an attractive target for future research. Further studies are needed to determine the efficacy and safety of PICART1 as a drug or biomarker in cancer treatment.

Protein Name: P53 Inducible Cancer Associated RNA Transcript 1

More Common Targets