Target Name: GGH
NCBI ID: G8836
Other Name(s): Folate conjugase | GH | Gamma-Glu-X carboxypeptidase | GGH_HUMAN | GATD10 | Conjugase | gamma-glutamyl hydrolase | Folylpolygammaglutamyl hydrolase | Gamma-glutamyl hydrolase | gamma-Glu-X carboxypeptidase | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)

Exploring The Biology and Potential Applications of GGH, A Potential Drug Target Or Biomarker

GGH (Folate conjugase), a enzyme involved in the DNA replication process, has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative disorders, and genetic disorders. In this article, we will explore the biology of GGH and its potential as a drug target, as well as the current research on its potential utility as a drug target or biomarker.

GGH is a member of the DNA polymerase I (DNA-PCR) family, which is responsible for copying DNA in the cell. It is a crucial enzyme in the replication of DNA in eukaryotic cells, and is essential for the development and maintenance of tissue and organism. GGH is present in various organisms, including bacteria, archaea, and eukaryotes.

GGH has been shown to play a crucial role in the regulation of DNA replication in various organisms. In bacteria, GGH is involved in the regulation of DNA replication during the G-shaped S-phase of the cell cycle. In eukaryotes, GGH is involved in the regulation of DNA replication during the S-phase of the cell cycle and in the repair of DNA damage.

GGH has also been shown to be involved in the regulation of DNA replication in various diseases and conditions. For example, GGH has been shown to be involved in the development and progression of various types of cancer, including breast cancer, lung cancer, and colon cancer. In neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, GGH has been shown to be involved in the regulation of neurogenesis and the maintenance of neural tissue.

GGH has also been shown to be a potential drug target or biomarker in various diseases. For example, GGH has been shown to be a potential drug target for cancer, as it has been shown to play a role in the development and progression of various types of cancer. In addition, GGH has also been shown to be a potential biomarker for certain types of cancer, as it has been shown to be expressed in the urine and plasma of patients with certain types of cancer.

In addition to its potential as a drug target or biomarker, GGH has also been shown to have a variety of other biological functions. For example, GGH has been shown to play a role in the regulation of cellular processes such as cell growth, apoptosis, and cell signaling. It is also involved in the regulation of various cellular signaling pathways, including the T-cell receptor signaling pathway and the inhibition of apoptosis by the protein Bcl-2.

GGH is also involved in the regulation of DNA replication in various organisms, including bacteria, archaea, and eukaryotes. It is a crucial enzyme in the replication of DNA in eukaryotic cells, and is essential for the development and maintenance of tissue and organism. GGH is present in various organisms, including bacteria, archaea, and eukaryotes.

GGH has also been shown to play a role in the regulation of DNA replication in various diseases and conditions. For example, GGH has been shown to be involved in the development and progression of various types of cancer, including breast cancer, lung cancer, and colon cancer. In neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, GGH has been shown to be involved in the regulation of neurogenesis and the maintenance of neural tissue.

In addition to its potential as a drug target or biomarker, GGH has also been shown to have a variety of other biological functions. For example, GGH has been shown to play a role in the regulation of cellular processes such as cell growth, apoptosis, and cell signaling. It is also involved in the regulation of various cellular signaling pathways, including the T-cell receptor signaling pathway and the inhibition of apoptosis by the protein Bcl-2.

GGH is a crucial enzyme involved in the replication of DNA in eukaryotic cells. Its involvement in the development and progression of various types of cancer, as well as its potential as a drug target or biomarker, makes it an attractive target for research into the mechanisms of cancer and other diseases. Further research is needed to fully understand the role of GGH in

Protein Name: Gamma-glutamyl Hydrolase

Functions: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate (PubMed:11005824, PubMed:8816764). May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates

More Common Targets

GGN | GGNBP1 | GGNBP2 | GGPS1 | GGT1 | GGT2P | GGT3P | GGT5 | GGT6 | GGT7 | GGT8P | GGTA1 | GGTLC1 | GGTLC2 | GGTLC3 | GH1 | GH2 | GHDC | GHITM | GHR | GHRH | GHRHR | GHRL | GHRLOS | GHSR | GID4 | GID8 | GIGYF1 | GIGYF2 | GIHCG | GIMAP1 | GIMAP1-GIMAP5 | GIMAP2 | GIMAP3P | GIMAP4 | GIMAP5 | GIMAP6 | GIMAP7 | GIMAP8 | GIMD1 | GIN1 | GINM1 | GINS complex | GINS1 | GINS2 | GINS3 | GINS4 | GIP | GIPC1 | GIPC2 | GIPC3 | GIPR | GIT1 | GIT2 | GJA1 | GJA10 | GJA1P1 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJA9-MYCBP | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GK | GK2 | GK3 | GK5 | GKAP1 | GKN1 | GKN2 | GKN3P | GLA | GLB1 | GLB1L | GLB1L2 | GLB1L3 | GLC1C | GLCCI1 | GLCCI1-DT | GLCE | GLDC | GLDN | GLE1 | GLG1 | GLI1 | GLI2 | GLI3