GJB6: Key Protein in Blood-Brain Barrier and Cell Signaling (G10804)

Target Name: GJB6

NCBI ID: G10804

GJB6: Key Protein in Blood-Brain Barrier and Cell Signaling

GJB6 (Gap junction protein, beta 6 (connexin 30)) is a protein that is expressed in many different tissues in the body, including the brain, heart, and blood vessels. It is a key player in the formation and maintenance of the blood-brain barrier, which is a critical barrier that helps to protect the brain from harmful substances and diseases.

GJB6 is a member of the connexin family of proteins, which are known for their role in cell-cell junctions. These proteins help to regulate the movement of cells and allow them to communicate with one another. GJB6 is specifically involved in the formation of tight junctions, which are specialized junctions that form between cells and help to maintain the integrity of the blood-brain barrier.

GJB6 is also involved in the regulation of cell signaling and is a negative regulator of the protein PDZ/PIP3. PDZ/PIP3 is a signaling protein that is involved in many different processes in the brain, including the formation of memories and the regulation of pain. By regulating PDZ/PIP3, GJB6 helps to maintain the stability and integrity of the brain and is thought to be involved in the development of many neurological and psychiatric disorders.

In addition to its role in the blood-brain barrier and cell signaling, GJB6 is also a potential drug target. GJB6 has been shown to be involved in a number of different signaling pathways and has been shown to interact with many different proteins. This makes it an attractive target for researchers to study and potentially develop drugs that can modulate its activity.

One of the challenges in studying GJB6 as a drug target is its complex structure. GJB6 is a large protein with many different subunits, and it is not clear how to predict its activity or how to design drugs that specifically interact with its various subunits. However, researchers are making progress in understanding the structure and function of GJB6 and are developing techniques to study its activity.

In addition to its potential as a drug target, GJB6 is also an attractive biomarker for many different diseases. The blood-brain barrier is a critical barrier that helps to protect the brain from harmful substances and diseases, and GJB6 is involved in the formation and maintenance of this barrier. This makes it an potential biomarker for a number of different diseases, including neurological and psychiatric disorders.

GJB6 is also involved in many different signaling pathways and has been shown to interact with many different proteins. This makes it an attractive target for researchers to study and potentially develop drugs that can modulate its activity. By developing techniques to study its activity and identify its potential drug targets, researchers hope to use GJB6 as a tool to understand the underlying mechanisms of many different diseases and to develop new treatments.

In conclusion, GJB6 is a protein that is involved in many different processes in the body, including the formation and maintenance of the blood-brain barrier and the regulation of cell signaling. Its complex structure and its role in the development of many neurological and psychiatric disorders make it an attractive target for researchers to study and potentially develop drugs. As research continues to advance, it is likely that GJB6 will become a valuable tool for understanding the underlying mechanisms of many different diseases and for developing new treatments.

Protein Name: Gap Junction Protein Beta 6

Functions: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell

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