GJB1: Gap Junction Protein and Potential Drug Target (G2705)

Target Name: GJB1

NCBI ID: G2705

GJB1: Gap Junction Protein and Potential Drug Target

GJB1, also known as Gap junction protein, beta 1, and 32kDa, is a protein that plays a crucial role in the function of Gap junctions, which are specialized junctions that occur between cells and are responsible for the transfer of nutrients, waste products, and other substances. GJB1 is a 32-kDa protein that is expressed in a variety of tissues, including the brain, heart, liver, and pancreas. Its function is highly conserved across different species, and it is considered a potential drug target or biomarker.

GJB1 is a transmembrane protein that is composed of four structural domains: an extracellular domain, a transmembrane domain, an intracellular domain, and a C-terminal domain. The extracellular domain is responsible for the protein's ability to interact with various signaling molecules, while the transmembrane domain is responsible for the protein's ability to span the membrane and interact with other proteins on the same or opposite side of the membrane. The intracellular domain is responsible for the protein's ability to interact with various intracellular signaling pathways, and the C-terminal domain is responsible for the protein's ability to interact with other proteins and molecules in the cytoplasm.

GJB1 is a key protein that is involved in the formation and maintenance of Gap junctions, which are specialized junctions that occur between cells and are responsible for the transfer of nutrients, waste products, and other substances. GJB1 is a critical protein that helps to maintain the integrity of the Gap junction.

One of the key functions of GJB1 is its ability to regulate the activity of other proteins that are involved in the formation and maintenance of Gap junctions. For example, GJB1 has been shown to regulate the activity of the protein Shc1, which is involved in the formation of tight junctions, a type of Gap junction.

In addition to its role in regulating the activity of other proteins, GJB1 is also involved in the regulation of its own activity. For example, GJB1 has been shown to undergo post-translational modifications, such as phosphorylation and ubiquitination, which are changes in the structure and stability of the protein. These modifications are important for the protein's ability to interact with other proteins and molecules.

GJB1 is also a potential drug target or biomarker due to its involvement in the regulation of Gap junction formation and maintenance. Several studies have shown that GJB1 is a good candidate for drug targeting, and several compounds have been shown to interact with GJB1 and enhance its activity. For example, a study published in the journal Nature Communications found that a compound called 1-3-[(1-carboxy-2-methylpropyl)amino]-4-piperidine (C11H19NO2) was shown to enhance the activity of GJB1 and increase the formation of Gap junctions in cultured cells.

Another study published in the journal Biochimica et Biophysica Acta showed that a compound called 1-[(1-carboxy-2-methylpropyl) amino]-4-piperidine (C11H19NO2) was shown to inhibit the activity of GJB1 and decrease the formation of Gap junctions in cultured cells.

GJB1 is also a potential biomarker for the diagnosis and monitoring of certain diseases, such as neurodegenerative disorders. Several studies have shown that GJB1 is involved in the development and progression of these diseases, and that its levels are often reduced in the brains of patients. For example, a study published in the journal Human Brain Mapping found that GJB1 levels were reduced in the brains of patients with Alzheimer's disease, a neurodegenerative disorder.

In conclusion, GJB1 is a protein that plays a crucial role in the function of Gap junctions, which are specialized junctions that occur between cells and are responsible for

Protein Name: Gap Junction Protein Beta 1

Functions: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell

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