SLC25A51: A Mitochondrial NAD(+) Transporter and Potential Drug Target

Target Name: SLC25A51

NCBI ID: G92014

SLC25A51: A Mitochondrial NAD(+) Transporter and Potential Drug Target

Introduction

Nicotinamide adenine dinucleotide (NAD+) is a crucial coenzyme for many cellular processes, including energy metabolism, DNA replication, and signaling pathways. Mitochondria are organelles responsible for generating the majority of the energy for the cell through a process called cellular respiration. The mitochondrial NAD+ transporter, SLC25A51, plays a significant role in regulating the levels of NAD+ in the mitochondria, which is critical for the proper functioning of the cell.

SLC25A51 is a protein that is expressed in most tissues and is primarily localized to the mitochondria. It is a member of the SLC transporter family, which includes proteins that transport various nucleotides, including NAD+, FAD, and ATP. SLC25A51 is responsible for transmitting NAD+ from the mitochondria to the cytoplasm, where it can be used by various cellular processes.

SLC25A51 functions as a mitochondrial NAD+ transporter by participating in the transport of NAD+ from the mitochondria to the cytoplasm. It has four unique subunits, A, B, C, and D, which are encoded by the genes Slc25A51, Slc25A52, Slc25A53, and Slc25A54 , respectively. SLC25A51 is a 21-kDa protein that has a calculated pI of 6.3. The protein has a highly conserved N-terminus, which is known to be involved in the formation of inclusion domains.

SLC25A51 is expressed in most tissues and is primarily localized to the mitochondria. It is a mitochondrial NAD+ transporter that is responsible for transmitting NAD+ from the mitochondria to the cytoplasm. It has four unique subunits, A, B, C, and D, which are encoded by the genes Slc25A51, Slc25A52, Slc25A53, and Slc25A54, respectively. SLC25A51 is a 21-kDa protein that has a calculated pI of 6.3. The protein has a highly conserved N-terminus, which is known to be involved in the formation of inclusion domains.

SLC25A51 plays a crucial role in the regulation of cellular processes, including energy metabolism, DNA replication, and signaling pathways. It is involved in the transfer of NAD+ from the mitochondria to the cytoplasm, which is critical for the proper functioning of the cell. is a potential drug target and may be used to treat various diseases associated with mitochondrial dysfunction, such as Alzheimer's disease, Parkinson's disease, and cardiovascular disease.

Conclusion

SLC25A51 is a mitochondrial NAD+ transporter that is responsible for transmitting NAD+ from the mitochondria to the cytoplasm. It is a crucial protein that plays a critical role in the regulation of cellular processes, including energy metabolism, DNA replication, and signaling pathways. SLC25A51 may be a potential drug target and could be used to treat various diseases associated with mitochondrial dysfunction.

Protein Name: Solute Carrier Family 25 Member 51

Functions: Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria (PubMed:32906142, PubMed:33262325). Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration (PubMed:32906142, PubMed:33262325). Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria (PubMed:32906142)

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