SLC34A1: A Protein Involved in Cell Regulation and Disease Development

Target Name: SLC34A1

NCBI ID: G6569

SLC34A1: A Protein Involved in Cell Regulation and Disease Development

SLC34A1 (NPT2) is a protein that is expressed in various tissues throughout the body. It is a member of the selective nuclear transport (SNT) family, which is responsible for the transport of nucleotides, including DNA and RNA, across the nuclear membrane. SLC34A1 is also known as NPT2, which stands for Nucleotide Transfer Protein 2.

SLC34A1 is a 21-kDa protein that is expressed in the brain, heart, and pancreas. It is primarily localized to the nuclei of brain cells and is involved in the transport of various nucleotides across the nuclear membrane. SLC34A1 is also involved in the regulation of gene expression and has been shown to play a role in the development and progression of various diseases, including cancer.

One of the unique features of SLC34A1 is its ability to transport nucleotides across the nuclear membrane in a specific direction, which is determined by the conformation of the protein. SLC34A1 has four transmembrane domains: an N-terminal alpha-helix, a beta-sheet, a gamma-helix, and an N-terminal carboxy-tail. The N-terminal alpha-helix is responsible for the regulation of the protein's stability and functions, while the beta-sheet and gamma-helix are involved in the protein's structure and stability. The N-terminal carboxy-tail is responsible for the regulation of the protein's interactions with other proteins and nucleotides.

SLC34A1 has been shown to play a role in the regulation of various cellular processes, including cell growth, apoptosis, and DNA replication. For example, studies have shown that SLC34A1 is involved in the regulation of cell cycle progression and has been shown to promote the G1/S transition, which is the stage of the cell cycle where the cell prepares for cell division.

In addition to its role in cell regulation, SLC34A1 has also been shown to be involved in the development and progression of various diseases, including cancer. For example, studies have shown that SLC34A1 is involved in the regulation of the angiogenesis (the formation of new blood vessels) that occurs in cancer and has been shown to play a role in the development of cancer.

SLC34A1 has also been shown to be involved in the regulation of DNA replication, which is the process by which a cell makes a copy of its DNA. Studies have shown that SLC34A1 is involved in the regulation of DNA replication and has been shown to play a role in the development of cancer.

In conclusion, SLC34A1 (NPT2) is a protein that is involved in the regulation of various cellular processes, including cell growth, apoptosis, and DNA replication. It is also involved in the development and progression of various diseases, including cancer. As a drug target or biomarker, SLC34A1 is a promising target for the development of new treatments for a variety of diseases.

Protein Name: Solute Carrier Family 34 Member 1

Functions: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:26047794, PubMed:8327470, PubMed:12324554, PubMed:20335586). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity)

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