SLC36A4: A Drug Target / Disease Biomarker (G120103)

Target Name: SLC36A4

NCBI ID: G120103

SLC36A4: A Drug Target / Disease Biomarker

SLC36A4 is a protein that is expressed in the brain and is involved in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time. The SLC36A4 gene has been identified as a potential drug target for the treatment of various neurological disorders, including Alzheimer's disease and Parkinson's disease.

SLC36A4 is a member of the superfamily of transport proteins, known as the untranslocatable endoplasmic reticulum (URT) protein family. These proteins are involved in the delivery of various molecules across the endoplasmic reticulum, including neurotransmitters that regulate brain function. SLC36A4 is specifically involved in the delivery of dopamine across the endoplasmic reticulum, which is a neurotransmitter that plays a crucial role in motivation, pleasure, and mood regulation.

SLC36A4 is also involved in the regulation of the levels of a protein called synaptophysin, which is involved in the formation and maintenance of synapses, the structural elements that connect neurons in the brain. SLC36A4 has been shown to play a role in the regulation of synaptophysin levels, which may be important for the proper functioning of synapses.

SLC36A4 is also involved in the regulation of the stress response, which is an important aspect of brain function that helps the brain to respond to various stressors, including physical stress, mental stress, and environmental stress. SLC36A4 has been shown to play a role in the regulation of the stress response, which may be important for the treatment of stress-related disorders.

In addition to its role in synaptic plasticity and stress response, SLC36A4 has also been shown to be involved in the regulation of inflammation, which is an important aspect of brain function that helps the brain to protect itself from harmful substances. SLC36A4 has been shown to play a role in the regulation of inflammation, which may be important for the treatment of various inflammatory disorders.

SLC36A4 is also involved in the regulation of the blood-brain barrier, which is the barrier that separates the brain from the blood and is responsible for controlling the entry of certain substances into the brain. SLC36A4 has been shown to play a role in the regulation of the blood-brain barrier, which may be important for the treatment of certain neurological disorders that are caused by the blockage of the blood-brain barrier, such as Alzheimer's disease.

In conclusion, SLC36A4 is a protein that is involved in the regulation of synaptic plasticity, stress response, inflammation, and the blood-brain barrier. As a potential drug target, SLC36A4 may be useful for the treatment of various neurological disorders, including Alzheimer's disease and Parkinson's disease. Further research is needed to fully understand the role of SLC36A4 in brain function and to develop effective treatments for these disorders.

Protein Name: Solute Carrier Family 36 Member 4

Functions: Uniporter that mediates the transport of neutral amino acids like L-tryptophan, proline and alanine (PubMed:21097500). The transport activity is sodium ions-independent, electroneutral and therefore functions via facilitated diffusion (PubMed:21097500)

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