Target Name: NPM3
NCBI ID: G10360
Other Name(s): Nucleoplasmin-3 | nucleophosmin/nucleoplasmin 3 | Nucleophosmin/nucleoplasmin 3 | PORMIN | Nucleophosmin/nucleoplasmin family, member 3 | nucleophosmin/nucleoplasmin family, member 3 | NPM3_HUMAN | TMEM123 | OTTHUMP00000020352

NPM3: A Protein Target for Cancer and other diseases

Nucleoplasmin-3 (NPM3) is a protein that is expressed in various cell types of the human body. It plays a crucial role in the regulation of cell growth, apoptosis, and DNA replication. The NPM3 gene has been implicated in the development and progression of various diseases, including cancer. As a result, NPM3 has become an attractive drug target and a potential biomarker for disease diagnosis and treatment.

The NPM3 protein is composed of several subunits that are responsible for different functions in the cell. The most well-known subunit is the NPM3 protein itself, which is a nucleosome-associated protein (NAP). The NPM3 protein forms a nucleosome, which is a protein-nucleic acid complex that is responsible for the packaging of DNA in the nucleus of the cell. The NPM3 protein helps to maintain the stability of the nucleosome and is involved in the regulation of DNA replication, transcription, and apoptosis.

Another well-known subunit of NPM3 is the NPM3-like protein (NLP). The NLP is a 22-kDa protein that is expressed in various cell types and is involved in the regulation of cell adhesion, migration, and invasion. It is also thought to play a role in the development and progression of cancer.

In addition to its role in cell regulation, NPM3 has also been linked to the development of various diseases. For example, NPM3 has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. It has also been implicated in the development of cancer, including breast, ovarian, and colorectal cancers.

As a result of its involvement in these diseases, NPM3 has become an attractive drug target for researchers. Researchers have been working to develop NPM3-based therapies and diagnostic tools to treat these diseases. One approach is to target the NPM3 protein directly with small molecules , such as drugs that can inhibit its activity. This approach has been successful in treating some diseases, such as breast cancer.

Another approach is to use NPM3 as a biomarker to diagnose and monitor the progression of disease. Researchers have developed techniques to detect NPM3 levels in various body fluids, such as blood, urine, and tissue. This has allowed them to monitor the effectiveness of NPM3 -based therapies and to identify individuals who are at risk for disease progression.

In conclusion, NPM3 is a protein that is involved in the regulation of cell growth, apoptosis, and DNA replication. Its role in the development and progression of various diseases has made it an attractive drug target and a potential biomarker for disease diagnosis and treatment. As research continues to advance, it is likely that NPM3 will play an increasingly important role in the development of new treatments for a variety of diseases.

Protein Name: Nucleophosmin/nucleoplasmin 3

Functions: Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning (PubMed:22362753, PubMed:20073534). Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM (PubMed:22362753). Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM (PubMed:15596447)

More Common Targets

NPNT | NPPA | NPPA-AS1 | NPPB | NPPC | NPR1 | NPR2 | NPR3 | NPRL2 | NPRL3 | NPS | NPSR1 | NPSR1-AS1 | NPTN | NPTN-IT1 | NPTX1 | NPTX2 | NPTXR | NPVF | NPW | NPY | NPY1R | NPY2R | NPY4R | NPY4R2 | NPY5R | NPY6R | NQO1 | NQO2 | NR0B1 | NR0B2 | NR1D1 | NR1D2 | NR1H2 | NR1H3 | NR1H4 | NR1I2 | NR1I3 | NR2C1 | NR2C2 | NR2C2AP | NR2E1 | NR2E3 | NR2F1 | NR2F1-AS1 | NR2F2 | NR2F2-AS1 | NR2F6 | NR3C1 | NR3C2 | NR4A1 | NR4A2 | NR4A3 | NR5A1 | NR5A2 | NR6A1 | NRAD1 | NRADDP | NRAP | NRARP | NRAS | NRAV | NRBF2 | NRBF2P4 | NRBP1 | NRBP2 | NRCAM | NRDC | NRDE2 | NREP | NRF1 | NRG1 | NRG2 | NRG3 | NRG4 | NRGN | NRIP1 | NRIP2 | NRIP3 | NRIP3-DT | NRIR | NRK | NRL | NRM | NRN1 | NRN1L | NRON | NRP1 | NRP2 | NRROS | NRSN1 | NRSN2 | NRSN2-AS1 | NRTN | NRXN1 | NRXN2 | NRXN2-AS1 | NRXN3 | NSA2 | NSA2P2