KLF2: A Potential Drug Target for Cancer and Other Diseases (G10365)

Target Name: KLF2

NCBI ID: G10365

KLF2: A Potential Drug Target for Cancer and Other Diseases

KLF2 (KLF2_HUMAN), a protein that plays a crucial role in cellular signaling pathways, has recently been identified as a potential drug target or biomarker for various diseases. The KLF2 gene, which encodes a protein with 21 amino acid residues, is located on chromosome 12q14 and has been implicated in various biological processes, including cell adhesion, migration, and invasion.

KLF2 is a non-coding RNA molecule that functions as a negative regulator of the NF-kappa signaling pathway. NF-kappa is a well-known protein that plays a central role in cell signaling, including cell growth, differentiation, and survival. The NF-kappa signaling pathway is a complex network of interactions that involves various proteins, including KLF2.

KLF2 functions as a negative regulator by binding to the NF-kappa1 receptor, which is a transmembrane protein that plays a central role in NF-kappa signaling. The binding of KLF2 to NF-kappa1 inhibits the activity of the receptor, thereby preventing the downstream signaling pathways that are driven by NF-kappa.

Recent studies have demonstrated that KLF2 is involved in various biological processes, including cancer progression, stem cell maintenance, and tissue repair. For example, KLF2 has been shown to be involved in the regulation of cell adhesion and migration, which are critical processes for the development and progression of cancer.

In addition to its role in cell signaling, KLF2 has also been shown to play a role in the regulation of gene expression. For example, KLF2 has been shown to interact with the transcription factor, p53, and can inhibit the activity of p53, thereby controlling the expression of target genes.

KLF2 has also been shown to play a role in the regulation of cellular immortalization. immortal cells are cells that have the ability to continuously divide and have an indefinite lifespan. KLF2 has been shown to be involved in the regulation of cellular immortalization, as it has been shown to play a role in the negative regulation of the p16INK4a gene, which is a key gene for cellular immortalization.

In conclusion, KLF2 is a protein that has been shown to play a critical role in various biological processes, including cell signaling, cell adhesion, migration, and immortalization. Its function as a negative regulator of the NF-kappa signaling pathway makes it an attractive target for drug development, as it has been shown to be involved in the regulation of various diseases, including cancer. Further research is needed to fully understand the role of KLF2 as a drug target or biomarker and to develop effective treatments for various diseases associated with its dysfunction.

Protein Name: KLF Transcription Factor 2

Functions: Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758)

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