KLK8: A Protein Implicated in Cell Signaling, Inflammation and Tissue Repair

Target Name: KLK8

NCBI ID: G11202

KLK8: A Protein Implicated in Cell Signaling, Inflammation and Tissue Repair

KLK8 (Serine Protease 19) is a protein that is expressed in a variety of tissues throughout the body. It is a member of the Kallikrein-related serine proteases (KLK) family, which are a group of serine proteases that are involved in the regulation of various cellular processes, including cell signaling, inflammation, and tissue repair.

KLK8 is a 19-kDa protein that is expressed in a variety of tissues, including liver, spleen, lung, heart, kidney, and pancreas. It is mainly localized to the cytoplasm of cells, where it can be detected by techniques such as immunofluorescence or Western blotting.

KLK8 has been shown to play a role in a variety of cellular processes. For example, it has been shown to be involved in the regulation of cell signaling, including the production of signals from G-protein-coupled receptors (GPCRs) and the regulation of cell proliferation.

In addition to its role in cellular signaling, KLK8 has also been shown to be involved in the regulation of inflammation. For example, it has been shown to play a role in the regulation of inflammation-related signaling pathways, including the production of pro-inflammatory cytokines and the regulation of the immune response.

KLK8 has also been shown to be involved in the regulation of tissue repair. For example, it has been shown to play a role in the regulation of cell proliferation and the production of new tissues during wound healing.

Despite its involvement in a variety of cellular processes, KLK8 has not yet been identified as a drug target or biomarker. However, its potential role in the regulation of cellular processes makes it a promising target for future research.

In conclusion, KLK8 is a protein that is expressed in a variety of tissues throughout the body and is involved in a variety of cellular processes. Further research is needed to determine its potential role in drug targeting and as a biomarker for various diseases.

Protein Name: Kallikrein Related Peptidase 8

Functions: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury

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