Kinase Non-Catalytic C-Lobe Domain Containing 1 (KNDC1) as A Drug Target and Biomarker

Target Name: KNDC1

NCBI ID: G85442

Kinase Non-Catalytic C-Lobe Domain Containing 1 (KNDC1) as A Drug Target and Biomarker

Kinase non-catalytic C-lobe domain containing 1 (KNDC1) is a protein that is expressed in various tissues throughout the body. It is a non-catalytic kinase that is involved in various cellular processes, including cell signaling, cell adhesion, and neurotransmission . Despite its importance in cellular signaling, little is known about KNDC1 and its potential as a drug target or biomarker. In this article, we will explore the biology and potential utility of KNDC1 as a drug target and biomarker.

Structure and Function

KNDC1 is a 21-kDa protein that is characterized by the presence of a N-terminal kinase non-catalytic C-lobe domain (N-KL domain) and a C-terminus that contains a single amino acid residue. The N-KL domain is a unique feature that is found only in a small number of non-catalytic kinases, and it is involved in the regulation of cellular processes such as cell signaling, cell adhesion, and neurotransmission.

The N-KL domain is composed of a unique open framework that is formed by the presence of a nucleotide exchange site, a conserved water molecule, and a short amino acid loop. This domain is known to be involved in the regulation of protein-protein interactions and in the control of protein stability.

KNDC1 is a non-catalytic kinase that is involved in the regulation of various cellular processes. It is expressed in various tissues throughout the body, including the brain, pancreas, and heart. It is involved in the regulation of cell signaling, cell adhesion, and neurotransmission.

Drug Target Potential

KNDC1 is a potential drug target due to its unique structure and function. The N-KL domain is known to be involved in the regulation of protein-protein interactions and in the control of protein stability, making it a potential target for small molecules that can modulate these processes. Additionally, the N-KL domain is also known to be involved in the regulation of cellular signaling, making it a potential target for drugs that can modulate signaling pathways.

Biomarker Potential

KNDC1 is also a potential biomarker for various diseases. The N-KL domain is involved in the regulation of cellular signaling, making it a potential target for drugs that can modulate signaling pathways. This suggests that KNDC1 may be a useful biomarker for diseases that are characterized by the disruption of cellular signaling pathways.

Conclusion

KNDC1 is a protein that is expressed in various tissues throughout the body and is involved in the regulation of various cellular processes. Its unique structure and function make it a potential drug target and biomarker. Further research is needed to fully understand the role of KNDC1 in cellular signaling and its potential as a drug target and biomarker.

Protein Name: Kinase Non-catalytic C-lobe Domain Containing 1

Functions: RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352)

More Common Targets