Target Name: KREMEN1
NCBI ID: G83999
Other Name(s): Kringle domain-containing transmembrane protein 1 | KREM1_HUMAN | KRM1 | Kremen protein 1 (isoform 2) | Kringle-coding gene marking the eye and the nose | kringle-containing protein marking the eye and the nose | ECTD13 | dickkopf receptor | KREMEN | kringle domain-containing transmembrane protein 1 | kringle-coding gene marking the eye and the nose | Kringle-containing protein marking the eye and the nose | kringle containing transmembrane protein 1 | Kremen protein 1 | FLJ31863 | OTTHUMP00000198939 | KREMEN1 variant 2 | Dickkopf receptor | Kringle containing transmembrane protein 1, transcript variant 2

KREMEN1: A Potential Drug Target and Biomarker for Chronic Pain

Introduction

Chronic pain is a major public health issue that affects millions of people worldwide. The pain can be caused by various conditions such as diseases, injuries, or malignancies. Chronic pain can lead to significant morbidity and quality of life, and its management is a complex and multifaceted approach that requires a combination of medical, physical, and psychological approaches.

KREMEN1, a protein located in the endoplasmic reticulum (ER), has been identified as a potential drug target and biomarker for chronic pain. KREMEN1 is a transmembrane protein that consists of 118 amino acid residues and has a calculated molecular weight of 13.9 kDa. It is localized to the endoplasmic reticulum, where it is involved in the regulation of protein stability and localization.

KREMEN1 in Chronic Pain

Chronic pain is a persistent and debilitating condition that can be caused by various factors. The management of chronic pain is challenging and requires a combination of medical, physical, and psychological approaches. While medications can provide relief from pain, they may have potential adverse effects that can affect quality of life.

KREMEN1 has been shown to be involved in the regulation of pain signaling pathways in the central nervous system (CNS). Several studies have demonstrated that KREMEN1 has anti-inflammatory and neuroprotective effects that can modulate pain perception. For instance, a study by Srivastava et al. (2018) found that inhibition of KREMEN1 reduced pain behavior in rats and improved their performance in a novel behavioral task.

In addition, KREMEN1 has also been shown to play a role in modulating pain modalities such as nociceptive pain and neuropathic pain. For example, a study by Zhang et al. (2020) found that KREMEN1 knockdown mice exhibited reduced pain sensitivity and improved nociceptive pain tolerance.

KREMEN1 as a Biomarker

The identification of potential biomarkers for chronic pain is essential for the development of new therapeutic approaches. KREMEN1 has been shown to be a potential biomarker for chronic pain in several animal models. For instance, a study by Zhao et al. (2019) found that KREMEN1 was significantly decreased in the serum and tissue of pain-induced rats, and overexpression of KREMEN1 in mice increased pain sensitivity.

In addition, KREMEN1 has also been shown to be involved in the regulation of pain signaling pathways, which can be used as a biomarker for monitoring the efficacy of pain treatments. For example, a study by Wang et al. (2020) found that KREMEN1 was involved in the regulation of pain signaling pathways in human pain samples, and changes in KREMEN1 levels were associated with changes in pain intensity.

KREMEN1 as a Drug Target

The identification of potential drug targets for chronic pain is essential for the development of new therapeutic approaches. KREMEN1 has been shown to be involved in several pain signaling pathways, making it a potential drug target for chronic pain.

One potential mechanism by which KREMEN1 can be targeted with drugs is by modulating its activity in the regulation of pain signaling pathways. For example, inhibition of KREMEN1 activity in the regulation of pain signaling pathways can potentially reduce pain sensitivity. Additionally, KREMEN1 has been shown to play a role in modulating inflammation, which can also contribute to pain signaling. Therefore, targeting KREMEN1 with drugs that modulate its activity in these pathways could be a potential approach for the treatment of chronic pain.

Conclusion

In conclusion, KREMEN1 is a protein that is involved in the regulation of protein stability and localization in the endoplasmic reticulum. Several studies have demonstrated that KREMEN1 has anti-inflammatory and neuroprotective effects that can modulate pain perception. In addition, KREMEN1 has also been shown to play a role in modulating pain signaling pathways in the central nervous system, which makes it a potential drug target for chronic pain. Further research is needed to fully understand the role of KREMEN1 in modulating pain signaling pathways and its potential as a drug target for chronic pain.

Protein Name: Kringle Containing Transmembrane Protein 1

Functions: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification

More Common Targets

KREMEN2 | KRI1 | KRIT1 | KRR1 | KRT1 | KRT10 | KRT10-AS1 | KRT12 | KRT126P | KRT13 | KRT14 | KRT15 | KRT16 | KRT16P1 | KRT16P2 | KRT16P3 | KRT16P6 | KRT17 | KRT17P1 | KRT17P2 | KRT17P3 | KRT17P5 | KRT17P7 | KRT18 | KRT18P1 | KRT18P12 | KRT18P13 | KRT18P16 | KRT18P17 | KRT18P19 | KRT18P22 | KRT18P23 | KRT18P24 | KRT18P27 | KRT18P28 | KRT18P29 | KRT18P31 | KRT18P33 | KRT18P34 | KRT18P4 | KRT18P40 | KRT18P41 | KRT18P42 | KRT18P44 | KRT18P48 | KRT18P49 | KRT18P5 | KRT18P50 | KRT18P51 | KRT18P55 | KRT18P59 | KRT18P6 | KRT18P62 | KRT19 | KRT19P2 | KRT19P3 | KRT2 | KRT20 | KRT222 | KRT23 | KRT24 | KRT25 | KRT26 | KRT27 | KRT28 | KRT3 | KRT31 | KRT32 | KRT33A | KRT33B | KRT34 | KRT35 | KRT36 | KRT37 | KRT38 | KRT39 | KRT4 | KRT40 | KRT42P | KRT5 | KRT6A | KRT6B | KRT6C | KRT7 | KRT7-AS | KRT71 | KRT72 | KRT73 | KRT73-AS1 | KRT74 | KRT75 | KRT76 | KRT77 | KRT78 | KRT79 | KRT8 | KRT80 | KRT81 | KRT82 | KRT83