Potential Drug Target for Kidney and Blood Pressure Diseases: KRT18

Target Name: KRT18

NCBI ID: G3875

Potential Drug Target for Kidney and Blood Pressure Diseases: KRT18

KRT18 (Kidney Relaxin Receptor 18) is a protein that is expressed in the kidney, and it is known for its role in regulation of blood pressure, proteinuria, and incontinence in humans. It is a potential drug target in the treatment of various diseases, including diabetes, hypertension, and kidney diseases.

KRT18 is a member of the serpina family, which is a family of transmembrane proteins that regulate various physiological processes in the body, including blood pressure and protein transport. The serpina family has been identified as a potential drug target in the treatment of various diseases, including heart failure, hypertension, and diabetes.

KRT18 is expressed in the kidney and is involved in the regulation of proteinuria and incontinence. It is a potential drug target for diseases that affect the kidneys, such as diabetes, hypertension, and kidney diseases.

KRT18 is also involved in the regulation of blood pressure, which is a critical factor in the development and progression of various diseases, including heart failure, hypertension, and diabetes. High blood pressure can cause damage to the blood vessels, leading to complications such as heart failure, stroke, and kidney disease.

KRT18 has also been identified as a potential biomarker for the diagnosis and progression of various diseases, including diabetes and hypertension. It may be used as a diagnostic tool to determine the level of blood pressure and proteinuria in individuals with hypertension or diabetes.

In conclusion, KRT18 is a protein that is expressed in the kidney and is involved in the regulation of various physiological processes in the body, including blood pressure and protein transport. It is a potential drug target for the treatment of diseases that affect the kidneys, including diabetes, hypertension, and kidney diseases. It may also be used as a biomarker for the diagnosis and progression of these diseases. Further research is needed to determine the full role of KRT18 in these processes and to develop effective treatments.

Protein Name: Keratin 18

Functions: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection

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