KRT38: A Protein Implicated in Various Physiological Processes and Diseases

Target Name: KRT38

NCBI ID: G8687

KRT38: A Protein Implicated in Various Physiological Processes and Diseases

KRT38 (HHA8) is a protein that is expressed in various tissues of the human body, including the brain, lungs, heart, and gastrointestinal tract. It is a member of the heat shock protein (HSP) family, which are proteins that are expressed in response to increased levels of thermal stress in the body.

HSPs are known for their ability to withstand high levels of thermal stress and to maintain their stability in the face of adverse conditions, such as infection, UV radiation, and chemical exposure. This is achieved through the presence of multiple unique domains, including a cis-regulated N-terminal transmembrane domain, a core-mediating domain, and a C-terminal protein-coding domain.

KRT38 is a 21-kDa protein that is expressed in the heart, lung, and brain. It is localized to the endoplasmic reticulum (ER) and is predominantly expressed in the cardiac fibroblasts, which are responsible for the production of heart tissue. KRT38 is also expressed in the airway smooth muscle cells of the lungs and in the glial cells of the brain.

KRT38 has been shown to play a role in various physiological processes in the body. For example, it has been shown to be involved in the regulation of cell growth, cell survival, and cell proliferation. KRT38 has also been shown to be involved in the regulation of the immune response, as it has been shown to interact with the protein PDGF-BB.

KRT38 is also a potential drug target in the treatment of various diseases. For example, KRT38 has been shown to be involved in the development and progression of heart failure, a condition that affects the heart's ability to pump blood throughout the body. Researchers have shown that KRT38 levels are decreased in patients with heart failure, and that inhibiting its activity may be a potential therapy for this disease.

In addition, KRT38 has also been shown to be involved in the development and progression of cancer. For example, KRT38 has been shown to be expressed in various types of cancer, including breast, lung, and ovarian cancer. Researchers have shown that KRT38 levels are increased in cancer cells, and that inhibiting its activity may be a potential therapy for cancer.

Overall, KRT38 is a protein that has been shown to play a role in various physiological processes in the body and has been shown to be involved in the development and progression of various diseases. As such, it is a potential drug target for the treatment of a wide range of conditions.

Protein Name: Keratin 38

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