KRTAP15-1: A Potential Drug Target and Biomarker (G254950)

Target Name: KRTAP15-1

NCBI ID: G254950

Other Name(s): Keratin associated protein 15-1 | Keratin-associated protein 15-1 | KR151_HUMAN | keratin associated protein 15-1 | KAP15.1

KRTAP15-1: A Potential Drug Target and Biomarker

Keratin associated protein 15-1 (KRTAP15-1) is a protein that is expressed in a variety of tissues, including hair, nails, and skin. It is a member of the keratin gene family, which is responsible for the production of the protein that makes up the hair and nails. KRTAP15-1 has been identified as a potential drug target and biomarker due to its unique structure and expression pattern.

The KRTAP15-1 protein is composed of 155 amino acid residues and has a calculated molecular weight of 19.9 kDa. It is expressed in a variety of tissues, including hair, nails, and skin, and is also found in the extracellular matrix (ECM) of connective tissue. KRTAP15-1 is highly expressed in the ECM, which suggests that it may be involved in the structure and function of connective tissue.

One of the key features of KRTAP15-1 is its localization to the ECM. It is located in the middle of the ECM, which suggests that it may be involved in the organization and stability of connective tissue. Additionally, KRTAP15-1 is highly co-expressed with other ECM proteins, including collagen and laminin, which further supports its role in connective tissue.

Another potential drug target for KRTAP15-1 is its role in the development and progression of skin cancer. KRTAP15-1 has been shown to be highly expressed in skin cancer tissues, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Additionally, it has been shown to be involved in the development of metastatic skin cancers, which suggests that it may be a useful biomarker for monitoring the effectiveness of anti-cancer therapies.

In addition to its potential role in skin cancer, KRTAP15-1 may also be involved in the treatment of other conditions. Its localization to the ECM suggests that it may be involved in the organization and stability of connective tissue, which may be relevant to a variety of connective tissue disorders. Additionally, its role in the development and progression of skin cancer may make it a potential target for anti-cancer therapies.

KRTAP15-1 has also been identified as a potential biomarker for other conditions. For example, it has been shown to be highly expressed in the skin and hair of individuals with Alzheimer's disease, which suggests that it may be involved in the development and progression of this debilitating condition. Additionally, KRTAP15-1 has been shown to be involved in the development and progression of other neurological conditions, including Parkinson's disease and multiple sclerosis.

In conclusion, KRTAP15-1 is a protein that has been identified as a potential drug target and biomarker. Its unique structure and expression pattern, as well as its localization to the ECM and its involvement in the development and progression of skin cancer, make it an attractive target for further investigation. Further studies are needed to determine the full role of KRTAP15-1 in these conditions and to develop effective therapies that target this protein.

Protein Name: Keratin Associated Protein 15-1

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

More Common Targets