KRTAP3-3: A Potential Drug Target and Biomarker (G85293)

Target Name: KRTAP3-3

NCBI ID: G85293

KRTAP3-3: A Potential Drug Target and Biomarker

Keratin-associated protein 3-3 (KRTAP3-3) is a protein that is expressed in a variety of tissues, including hair, skin, and nails. It is a member of the keratin gene family, which is responsible for the production of the protein keratin, which is a component of hair, skin, and nails. KRTAP3-3 has been shown to play a role in the regulation of cell growth, differentiation, and survival.

Recent studies have suggested that KRTAP3-3 may have potential as a drug target or biomarker. For example, KRTAP3-3 has been shown to be involved in the development and progression of various diseases, including cancer. Additionally, KRTAP3-3 has been shown to be involved in the regulation of skin texture and pigmentation, which can be useful as a biomarker for skin health.

One potential mechanism by which KRTAP3-3 may be involved in the development and progression of cancer is by contributing to the regulation of cell growth and survival. For example, studies have shown that KRTAP3-3 can be involved in the regulation of cell cycle progression and the execution of cell division. Additionally, KRTAP3-3 has been shown to play a role in the regulation of apoptosis, which is the process by which cells undergo programmed cell death.

Another potential mechanism by which KRTAP3-3 may be involved in the development and progression of cancer is by contributing to the regulation of angiogenesis, which is the process by which new blood vessels are formed. KRTAP3-3 has been shown to be involved in the regulation of angiogenesis and has been shown to play a role in the development of various diseases, including cancer.

In addition to its potential role in cancer development, KRTAP3-3 has also been suggested as a potential drug target. For example, studies have shown that KRTAP3-3 can be targeted by small molecules and has a predicted binding affinity of 7 nM. Additionally, KRTAP3-3 has been shown to be involved in the regulation of various cellular processes, including cell adhesion, migration, and survival, which could make it a potential target for small molecules with pharmacological activity.

In conclusion, KRTAP3-3 is a protein that has been shown to play a role in a variety of cellular processes, including cell growth, differentiation, and apoptosis. Its potential as a drug target or biomarker makes it an attractive target for further research and may have the potential to contribute to the development of new treatments for a variety of diseases.

Protein Name: Keratin Associated Protein 3-3

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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