KRTAP4-5: A Potential Drug Target and Biomarker (G85289)

Target Name: KRTAP4-5

NCBI ID: G85289

KRTAP4-5: A Potential Drug Target and Biomarker

Keratin-associated protein 4.5 (KRTAP4-5) is a protein that has been identified as a potential drug target and biomarker in the field of skin diseases. KRTAP4-5 is a 25-kDa protein that is expressed in various tissues, including skin, hair, and nails. It is highly conserved in both humans and animals and has been shown to be involved in various physiological processes, including cell signaling, migration, and invasion.

One of the key functions of KRTAP4-5 is its role in the regulation of cell growth and differentiation. KRTAP4-5 has been shown to play a negative role in the development of cancer, and it is thought to do so by regulating cell proliferation and survival. This protein has also been shown to be involved in the regulation of cell migration and invasion, which are important processes in the development of skin diseases.

In addition to its role in cell biology, KRTAP4-5 is also thought to be involved in the regulation of inflammation. This protein has been shown to be involved in the regulation of immune cell function and has been shown to play a negative role in the development of skin inflammatory diseases.

As a potential drug target, KRTAP4-5 is of interest because of its involvement in various physiological processes that are important for the development and progression of skin diseases. This protein is also thought to be a good biomarker for the diagnosis and progression of skin diseases, making it an attractive target for drug development.

In conclusion, KRTAP4-5 is a protein that has been identified as a potential drug target and biomarker in the field of skin diseases. Its role in the regulation of cell biology, inflammation, and skin disease progression makes it an attractive target for drug development. Further research is needed to fully understand the functions of KRTAP4-5 and its potential as a drug target and biomarker.

Protein Name: Keratin Associated Protein 4-5

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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