KRTAP4-3: A Potential Drug Target and Biomarker (G85290)

Target Name: KRTAP4-3

NCBI ID: G85290

KRTAP4-3: A Potential Drug Target and Biomarker

KRTAP4-3 (Krataapide) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the KRTAP family, which includes several related proteins that play important roles in cellular signaling pathways . In recent years, KRTAP4-3 has gained significant interest as a potential drug target due to its involvement in several diseases, including neurodegenerative disorders, diabetes, and hypertension.

The KRTAP4-3 protein is known for its role in intracellular signaling, particularly in the regulation of mitochondrial function and energy metabolism. It is a key regulator of the mitochondrial dynamics, which is critical for the proper functioning of the cell. KRTAP4-3 is involved in the transfer of electrons from the mitochondria to the cytoplasm, which is essential for the production of ATP energy.

In neurodegenerative disorders, KRTAP4-3 has been implicated in the pathology of neurodegeneration. For example, studies have shown that KRTAP4-3 is overexpressed in the brains of individuals with Alzheimer's disease, which is a neurodegenerative disorder that is characterized by the progressive loss of brain cells. Additionally, loss of KRTAP4-3 has been observed in the brains of individuals with Parkinson's disease, another neurodegenerative disorder. These findings suggest that KRTAP4-3 may play a crucial role in the development and progression of neurodegenerative disorders.

In addition to its involvement in neurodegenerative disorders, KRTAP4-3 has also been linked to several other diseases, including diabetes and hypertension. Diabetes is a chronic metabolic disorder that is characterized by high levels of blood sugar and the failure of the body to produce or use insulin. KRTAP4-3 has been shown to be involved in the regulation of insulin sensitivity and glucose metabolism, which are critical for the management of diabetes.

Hypertension, or high blood pressure, is a common cardiovascular disease that can lead to a range of complications, including heart failure, stroke, and kidney damage. KRTAP4-3 has been shown to be involved in the regulation of blood pressure, and deficiencies in KRTAP4-3 have been observed in individuals with hypertension. These findings suggest that KRTAP4-3 may be a promising biomarker for the diagnosis and treatment of hypertension.

In conclusion, KRTAP4-3 is a protein that has significant involvement in various cellular signaling pathways, including intracellular signaling and energy metabolism. Its involvement in neurodegenerative disorders, diabetes, and hypertension has led to its gaining significant interest as a potential drug target. Further research is needed to fully understand the role of KRTAP4-3 in these diseases and to develop effective treatments.

Protein Name: Keratin Associated Protein 4-3

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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