KRTAP21-2: A Potential Drug Target and Biomarker (G337978)

Target Name: KRTAP21-2

NCBI ID: G337978

Other Name(s): Keratin-associated protein 21-2 | KR212_HUMAN | Keratin associated protein 21-2 | keratin associated protein 21-2 | KAP21.2

KRTAP21-2: A Potential Drug Target and Biomarker

Keratin-associated protein 21-2 (KRTAP21-2) is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function make it an intriguing target for researchers to explore.

KRTAP21-2 is a 21-kDa protein that is expressed in a variety of tissues, including brain, heart, skeletal muscles, and organs. It is highly conserved and has a similar distribution pattern as other known KRTAP proteins, which are involved in various cellular processes, including cytoskeletal organization, cell signaling, and tissue repair.

One of the key features of KRTAP21-2 is its ability to interact with various signaling molecules, including TGF-β, NF-kappa-B, and p53. These interactions suggest that KRTAP21-2 may play a role in regulating cellular processes that are important for tissue growth, repair, and survival.

In addition to its potential role in signaling pathways, KRTAP21-2 has also been shown to be involved in the regulation of cellular processes that are important for the development and progression of various diseases, including cancer. For example, studies have shown that KRTAP21-2 is involved in the regulation of cell proliferation, migration, and invasion, and that it can contribute to the development of cancer.

Furthermore, KRTAP21-2 has also been shown to be involved in the regulation of cellular processes that are important for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These studies have suggested that KRTAP21-2 may play a role in the development and progression of neurodegenerative diseases, and that it may be a potential drug target for these diseases.

In addition to its potential role in drug targeting and neurodegenerative diseases, KRTAP21-2 has also been shown to be involved in the regulation of autoimmune disorders. Studies have shown that KRTAP21-2 is involved in the regulation of T cell function, and that it may play a role in the development and progression of autoimmune disorders.

Overall, the unique structure and function of KRTAP21-2 make it an intriguing target for research into its potential drug targeting and biomarker properties. Further studies are needed to fully understand its role in these areas and to determine its potential as a drug target and biomarker.

Protein Name: Keratin Associated Protein 21-2

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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