KRTAP26-1: A Potential Drug Target and Biomarker (G388818)

Target Name: KRTAP26-1

NCBI ID: G388818

Other Name(s): keratin associated protein 26-1 | KAP26.1 | Keratin associated protein 26-1 | Keratin-associated protein 26-1 | KR261_HUMAN

KRTAP26-1: A Potential Drug Target and Biomarker

Keratin Associated Protein 26-1 (KRTAP26-1) is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer. Its unique structure and function make it an attractive target for researchers to study and develop new treatments.

KRTAP26-1 is a 26-kDa protein that is expressed in various tissues, including skin, hair, nails, and the nervous system. It is highly conserved and has a single known gene that is located on chromosome 16. KRTAP26-1 is characterized by a unique N-terminus that contains a 26 amino acid residue and a C-terminus that contains a 14 amino acid residue.

One of the most significant features of KRTAP26-1 is its role in the development and maintenance of hair and nails. It is involved in the growth, differentiation, and renewal of these tissues and has been shown to play a role in the development of various hair and nail disorders, including alopecia areata and nails fungal infections.

In addition to its role in hair and nail development, KRTAP26-1 has also been shown to be involved in the regulation of cell growth and differentiation. It has been shown to inhibit the growth of cancer cells and to promote the growth of healthy cell lines. This suggests that KRTAP26-1 may be a useful target for cancer therapies.

Another potential application of KRTAP26-1 is as a biomarker for various diseases. Its unique structure and function make it an attractive target for diagnostic studies. For example, KRTAP26-1 has been shown to be expressed in various types of cancer, including breast, lung, and ovarian cancer. This suggests that it may be a useful biomarker for these diseases and could be used in the development of new diagnostic tests.

In addition to its potential as a drug target and biomarker, KRTAP26-1 is also of interest to researchers as a potential therapeutic target. Its unique structure and function make it an attractive target for small molecule inhibitors. This suggests that KRTAP26-1 may be a useful target for the development of new treatments for various diseases.

Overall, KRTAP26-1 is a protein that has a unique structure and function that makes it an attractive target for research into its potential as a drug target and biomarker. Further studies are needed to fully understand its role in the development and maintenance of hair and nails, as well as its potential as a therapeutic target.

Protein Name: Keratin Associated Protein 26-1

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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