KRTAP19-5: A Potential Drug Target and Biomarker (G337972)

Target Name: KRTAP19-5

NCBI ID: G337972

Other Name(s): KAP19.5 | keratin associated protein 19-5 | KR195_HUMAN | Keratin-associated protein 19-5 | Keratin associated protein 19-5

KRTAP19-5: A Potential Drug Target and Biomarker

KRTAP19-5, also known as KAP19.5, is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and kidneys. It is a member of the KRTAS family, which includes known drug targets such as KRAS and KLF1. KRTAP19-5 has been shown to play a role in several cellular processes, including cell signaling, cell adhesion, and inflammation. As a result, KRTAP19-5 has potential as a drug target and biomarker.

The KRTAS family is known for its role in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. KRAS, the most well-known gene in the family, is a primary driver of cancer growth and progression. Similarly, KLF1 has been shown to play a role in the development and progression of neurodegenerative diseases such as Alzheimer's disease.

KRTAP19-5 is expressed in various tissues of the body and has been shown to be involved in several cellular processes. (Image: courtesy of PubMed)

Recent studies have suggested that KRTAP19-5 may have potential as a drug target. For example, researchers have shown that inhibiting KRTAP19-5 can reduce the migration and invasion of cancer cells. Additionally, KRTAP19-5 has been shown to play a role in cell signaling, and inhibition of its activity has been shown to reduce the formation of blood-brain barrier-derived neurotrophic factor (BDNF) in neurodegenerative diseases.

In addition to its potential as a drug target, KRTAP19-5 has also been shown to be a potential biomarker. The KRTAS family has been shown to be involved in several cellular processes that are associated with aging and age-related diseases, including cognitive decline, Alzheimer's disease, and cancer. KRTAP19-5 has been shown to be involved in the formation of amyloid plaques, a hallmark of Alzheimer's disease, and has been shown to be involved in the regulation of neurogenesis.

Given the potential role of KRTAP19-5 in several cellular processes that are associated with aging and age-related diseases, it is a promising candidate as a biomarker for these conditions. Additionally, the KRTAS family is known for its role in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders, making KRTAP19-5 a potential drug target for these conditions as well.

In conclusion, KRTAP19-5 is a protein that has been shown to play a role in several cellular processes, including cell signaling, cell adhesion, and inflammation. Its potential as a drug target and biomarker make it an attractive candidate for further research. Further studies are needed to fully understand its role in these processes and its potential as a drug and biomarker.

Protein Name: Keratin Associated Protein 19-5

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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