KRTAP12-4: A Potential Drug Target and Biomarker (G386684)

Target Name: KRTAP12-4

NCBI ID: G386684

KRTAP12-4: A Potential Drug Target and Biomarker

Keratin-associated protein 12-4 (KRTAP12-4) is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer. Its unique structure and function have made it an attractive target for researchers to investigate, and its potential as a drug may have significant implications for the treatment of these diseases.

The protein KRTAP12-4 is a member of the keratin family, which is known for their role in the development and maintenance of hair and nails. It is expressed in a variety of tissues, including skin, scalp, and hair, and has been implicated in the regulation of cell growth, differentiation, and survival.

One of the key features of KRTAP12-4 is its role in the development and maintenance of the hair cycle. It is known to play a key role in the regulation of the differentiation of hair follicles, and is involved in the process of follicular dystrophy. This disorder is characterized by the progressive loss of hair follicles, and is a common condition that affects millions of people worldwide.

KRTAP12-4 has also been shown to be involved in the regulation of cell survival and angiogenesis, which is the process by which new blood vessels are formed. This is important for the development and progression of many diseases, including cancer.

The potential drug target for KRTAP12-4 is its role in the regulation of cell survival and angiogenesis. Drugs that are able to inhibit the activity of this protein have the potential to be effective in treating a variety of diseases, including cancer.

In addition to its potential as a drug target, KRTAP12-4 has also been identified as a potential biomarker for several diseases. Its expression has been shown to be elevated in a variety of cancer types, including breast, ovarian, and prostate cancer. This suggests that it may be a useful biomarker for these diseases, and that its levels may be able to be used as a diagnostic tool.

The discovery and characterization of KRTAP12-4 as a potential drug target and biomarker has important implications for the treatment of a variety of diseases. Further research is needed to fully understand its function and potential as a drug, and to develop effective treatments for the diseases that are associated with its dysfunction.

Protein Name: Keratin Associated Protein 12-4

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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