KLRC4-KLRK1: A Drug Target / Disease Biomarker (G100528032)

Target Name: KLRC4-KLRK1

NCBI ID: G100528032

KLRC4-KLRK1: A Drug Target / Disease Biomarker

The KLRC4-KLRK1 gene is a non-coding RNA molecule that has been identified as a potential drug target or biomarker. The KLRC4 gene is located on chromosome 6 and encodes a protein known as KLRC4. KLRC4 is a key regulator of the microtubule network, which is a protein structure that plays a crucial role in the movement of cells and cell organelles. The KLRK1 gene is located on chromosome 18 and encodes a protein known as KLRK1. KLRK1 is a key regulator of the G-protein-coupled receptor (GPCR) family, which is a family of membrane receptors that play a crucial role in cellular signaling.

KLRC4 and KLRK1 have been shown to be involved in a wide range of cellular processes, including the regulation of cell growth, the control of cell division, and the regulation of the cytoskeleton. They have also been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Due to their involvement in a wide range of cellular processes, KLRC4 and KLRK1 have been identified as potential drug targets or biomarkers. Many drugs that are currently in use, such as taxol and gefitinib, work by inhibiting the activity of KLRC4 or KLRK1. These drugs are used to treat a wide range of diseases, including breast cancer, lung cancer, and neurodegenerative diseases.

In addition to their use as drugs, KLRC4 and KLRK1 have also been shown to be useful biomarkers for a wide range of diseases. For example, studies have shown that KLRC4 and KLRK1 levels can be used as biomarkers for cancer, neurodegenerative diseases, and autoimmune diseases.

Overall, the KLRC4-KLRK1 gene is a promising drug target or biomarker that has the potential to be used to treat a wide range of diseases. Further research is needed to fully understand the role of KLRC4 and KLRK1 in cellular signaling and the development of disease.

Protein Name: KLRC4-KLRK1 Readthrough

Functions: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4

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