KLHL23: A Protein Involved in Neural Activity and Stress Response

Target Name: KLHL23

NCBI ID: G151230

KLHL23: A Protein Involved in Neural Activity and Stress Response

Kelch-like protein 23 (KLHL23) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the Kelch family of proteins, which are characterized by the presence of a catalytic domain and a unique N-terminal region that is rich in conserved amino acid sequences.

KLHL23 is a 21-kDa protein that is expressed in the brain, heart, and kidneys, and has been shown to play a role in various physiological processes, including cell signaling, neurotransmitter synthesis, and stress response.

One of the unique features of KLHL23 is its ability to interact with other proteins, including the neurotransmitter GABA. This interaction between KLHL23 and GABA has been shown to play a role in the regulation of neural activity and sleep-wake cycles.

In addition to its role in neural activity, KLHL23 has also been shown to be involved in the regulation of inflammation and stress response. This is because of its ability to interact with factors such as KL and nuclear factor-kappa-B, which are involved in the regulation of inflammation and stress response.

KLHL23 is also a potential drug target, as its unique structure and function make it an attractive target for small molecule inhibitors. Researchers have identified several potential small molecule inhibitors that can interact with KLHL23 and have shown that these inhibitors can reduce the activity of KLHL23 in cell experiments.

In addition to its potential as a drug target, KLHL23 is also a potential biomarker for various diseases, including neurodegenerative diseases and psychiatric disorders. This is because of its expression in various tissues and its ability to interact with other proteins that are involved in the development and progression of these diseases.

Overall, KLHL23 is a protein that has important roles in various physiological processes, including cell signaling, neurotransmitter synthesis, and stress response. Its unique structure and function make it an attractive target for small molecule inhibitors, and its potential as a drug target and biomarker make it a valuable tool for the study of these processes.

Protein Name: Kelch Like Family Member 23

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