SDCCAG8: Negative Regulator of AP1 and Cadherin (G10806)

Target Name: SDCCAG8

NCBI ID: G10806

SDCCAG8: Negative Regulator of AP1 and Cadherin

SDCCAG8 (also known as HSPC085) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the superfamily of core transcription factors, which are a group of proteins that play a central role in the regulation of gene expression.

One of the key functions of SDCCAG8 is its role in cell signaling. It is a negative regulator of the transcription factor AP1, which is involved in the development and maintenance of tissues. By regulating the activity of AP1, SDCCAG8 helps to ensure that cells are able to accurately interpret the signals from their environment and respond accordingly.

In addition to its role in cell signaling, SDCCAG8 is also involved in the regulation of cellular processes such as cell adhesion, migration, and invasion. It is a critical regulator of the cadherin protein, which is involved in cell-cell adhesion, and has has been shown to play a role in the development of various types of cancer.

SDCCAG8 is also of interest as a potential drug target. Its involvement in the regulation of AP1 and its role in the regulation of cadherin protein make it a potential target for small molecule inhibitors. Additionally, its expression has been shown to be regulated by various signaling pathways, including TGF-β signaling, which may provide additional targets for drug development.

In conclusion, SDCCAG8 is a protein that is involved in a variety of cellular processes and its regulation by various signaling pathways. Its potential as a drug target makes it an attractive target for small molecule inhibitors. Further research is needed to fully understand its role in cell signaling and its potential as a therapeutic agent.

Protein Name: SHH Signaling And Ciliogenesis Regulator SDCCAG8

Functions: Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062)

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