SEC23B: A Potential Drug Target and Biomarker (G10483)

Target Name: SEC23B

NCBI ID: G10483

SEC23B: A Potential Drug Target and Biomarker

SEC23B, short for SEC23 homolog B, is a gene that encodes a protein known as copii coat complex component.SEC23B is a member of the SEC23 family, which is known for its role in regulating cell division and cytoskeletal organization. The SEC23 family has also been implicated in a variety of diseases, including cancer, neurodegenerative disorders, and developmental defects.

SEC23B is expressed in many different tissues and cells throughout the body, including the brain, spinal cord, and peripheral tissues. It is highly conserved, with significant sequence identity between different species.SEC23B has been shown to play a role in several cellular processes, including cytoskeletal organization, cell division, and transcriptional regulation.

One of the most significant functions of SEC23B is its role in regulating cytoskeletal organization.SEC23B is involved in the formation of the cytoskeleton and in the regulation of the actin filaments that organize the cytoskeleton. It has been shown to play a role in the regulation of cell division, with studies suggesting that it may be involved in the G1/S transition that occurs during cell division.

In addition to its role in cytoskeletal organization, SEC23B is also involved in transcriptional regulation. It has been shown to interact with a variety of transcription factors, including DNMT1 and HIF1?±.SEC23B has also been shown to play a role in the regulation of gene expression, with studies suggesting that it may be involved in the regulation of stem cell proliferation and differentiation.

Given the multiple functions of SEC23B, it is a promising candidate for drug targeting.SEC23B has been shown to interact with several drug targets, including the tyrosine kinase AKT1. This suggests that SEC23B may be a target for drugs that are designed to inhibit tyrosine kinase activity. In addition, SEC23B has been shown to play a role in the regulation of cell division, which may make it a target for drugs that are designed to disrupt cell division.

Another potential mechanism by which SEC23B may be targeted is its role in the regulation of neurodegenerative disorders.SEC23B has been implicated in the development and progression of a variety of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Given its role in the regulation of cell division and cytoskeletal organization, it is possible that SEC23B may be involved in the development and progression of neurodegenerative disorders.

In conclusion, SEC23B is a promising candidate for drug targeting due to its multiple functions and its potential involvement in a variety of neurodegenerative disorders. Further research is needed to fully understand the role of SEC23B in cellular processes and its potential as a drug target.

Protein Name: SEC23 Homolog B, COPII Coat Complex Component

Functions: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex

More Common Targets