SEMA4B: A Transmembrane Protein Potential Drug Target in Neurology

Target Name: SEMA4B

NCBI ID: G10509

SEMA4B: A Transmembrane Protein Potential Drug Target in Neurology

SEMA4B (semaphorin-C) is a protein that is expressed in various tissues throughout the body, including the brain, lungs, heart, kidneys, and intestines. It is a type of transmembrane protein that consists of four transmembrane domains and a cytoplasmic tail. SEMA4B is known for its role in the regulation of intracellular signaling pathways, including the NF-kappa pathway.

SEMA4B is a protein that has been identified as a potential drug target in the field of neurology. Studies have shown that SEMA4B is involved in the regulation of neurotransmitter release from neurons, which is important for the function of the brain. Additionally, SEMA4B has been shown to play a role in the regulation of pain perception and the modulation of pain modalities.

SEMA4B is also known as sephorin-C, which is a type of transmembrane protein that is characterized by the presence of a heparan sulfate proteoglycan (HSPG) domain on its cytoplasmic tail. HSPG domains are known for their ability to interact with various proteins and to play a role in the regulation of cellular signaling pathways.

SEMA4B is expressed in a variety of tissues throughout the body, including the brain, lungs, heart, kidneys, and intestines. It is a type of transmembrane protein that consists of four transmembrane domains and a cytoplasmic tail. SEMA4B is known for its role in the regulation of intracellular signaling pathways, including the NF-kappa pathway.

SEMA4B has been shown to play a role in the regulation of neurotransmitter release from neurons, which is important for the function of the brain. Studies have shown that SEMA4B is involved in the regulation of the release of dopamine, serotonin, and other neurotransmitters. Additionally, SEMA4B has been shown to play a role in the regulation of pain perception and the modulation of pain modalities.

SEMA4B is also known as sephorin-C, which is a type of transmembrane protein that is characterized by the presence of a heparan sulfate proteoglycan (HSPG) domain on its cytoplasmic tail. HSPG domains are known for their ability to interact with various proteins and to play a role in the regulation of cellular signaling pathways.

In conclusion, SEMA4B is a protein that has been identified as a potential drug target in the field of neurology. Studies have shown that SEMA4B is involved in the regulation of neurotransmitter release from neurons and in the regulation of pain perception and the modulation of pain modalities. Further research is needed to fully understand the role of SEMA4B in these processes and to determine its potential as a drug target.

Protein Name: Semaphorin 4B

Functions: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons

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