SEPTIN1: A Drug Target and Biomarker for Diverse Dysfunctions

Target Name: SEPTIN1

NCBI ID: G1731

SEPTIN1: A Drug Target and Biomarker for Diverse Dysfunctions

SEPTIN1, a gene product known as the protein-disulfide joiner (PDJ), is a key regulator of cytoskeletal structure and function in eukaryotic cells. It is a member of the SEPTIN family, which includes four structurally similar genes: SEPTIN1, SEPTIN2, SEPTIN3, and SEPTIN4. These genes encode for proteins that form the cytoskeleton and are involved in various cellular processes, including cell division, intracellular signaling, and tissue mechanics.

SEPTIN1 is a 21-kDa protein that is expressed in various tissues and cell types. It is highly conserved, with a predicted identity of 106 amino acids. The protein has four known functions, including:

1. Regulating cell division: SEPTIN1 is involved in the regulation of cell division by controlling the assembly and disassembly of microtubules, which are essential for cell growth and division.

2. Controlling cytoskeletal structure: SEPTIN1 helps to maintain the stability of the cytoskeleton by interacting with microtubules and preventing their breakdown.

3. Regulating cell signaling pathways: SEPTIN1 has been shown to be involved in various signaling pathways, including the TGF-β pathway, which plays a crucial role in cell growth, wound healing, and tissue regeneration.

4. Participating in the development and maintenance of tissues: SEPTIN1 is involved in the development and maintenance of tissues, including the regulation of tissue mechanics and the formation of organs.

SEPTIN1 has also been shown to be a potential drug target in various diseases. For example, SEPTIN1 has been associated with various types of cancer, including breast, ovarian, and prostate cancer. Additionally, SEPTIN1 has been linked to a variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

SEPTIN1 has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, SEPTIN1 has been shown to be elevated in the blood and urine of individuals with various types of cancer, making it a potential diagnostic biomarker. Additionally, SEPTIN1 has been shown to be decreased in individuals with neurodegenerative diseases, such as Alzheimer's disease, suggesting that it may be a potential therapeutic target.

In conclusion, SEPTIN1 is a protein that plays a crucial role in the regulation of cytoskeletal structure and function, as well as the development and maintenance of tissues. It is a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the functions of SEPTIN1 and its potential as a therapeutic target.

Protein Name: Septin 1

Functions: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)

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