SENP7: A Potential Drug Target and Biomarker for Sentrin-Specific Peptidase 7

Target Name: SENP7

NCBI ID: G57337

SENP7: A Potential Drug Target and Biomarker for Sentrin-Specific Peptidase 7

Sentrin-specific peptidase 7 (SENP7) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the superfamily of zinc-dependent enzymes, known as the zinc-dependent hydrolases, and is responsible for breaking down a specific type of peptidoglycan called sentrin.

Sentrin is a type of carbohydrate that is found in the cytoplasm of many cells, and it functions as a signaling molecule. It has been shown to play a role in various cellular processes, including cell signaling, cell adhesion, and neurotransmission.

SENP7 is a unique protein that is specific for sentrin, and it is the only known enzyme that is responsible for breaking down sentrin. It is expressed in high levels in the brain and is involved in the processing and degradation of sentrin.

SENP7 has been shown to play a role in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. It is also involved in the development of certain types of cancer, such as melanoma and colon cancer.

SENP7 may be a potential drug target for these disorders because it is involved in the processing and degradation of sentrin, which is a known risk factor for these conditions. Additionally, SENP7 may also be a biomarker for these disorders because it is expressed at high levels in the brain and may be able to be used as a diagnostic tool.

One way to target SENP7 is through the use of small molecules that can inhibit its activity. These small molecules can be found in natural compounds that are found in the environment, such as fruits and vegetables.

Another approach to target SENP7 is through the use of antibodies that are specific for SENP7. These antibodies can be used to target the protein in the body and may be used to treat certain disorders.

In conclusion, SENP7 is a unique protein that is specific for sentrin and is involved in the processing and degradation of this important carbohydrate. It is expressed in high levels in the brain and has been shown to play a role in various neurological and psychiatric disorders. As a result, SENP7 may be a potential drug target and biomarker for these disorders. Further research is needed to fully understand the role of SENP7 in these conditions and to develop effective treatments.

Protein Name: SUMO Specific Peptidase 7

Functions: Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455)

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