SEMA4F: Potential Drug Targets and Biomarkers for Various Diseases

Target Name: SEMA4F

NCBI ID: G10505

SEMA4F: Potential Drug Targets and Biomarkers for Various Diseases

SEMA4F, also known as Semaphorin-4F (Precursor), is a protein that is expressed in various tissues throughout the body. It is a member of the semaphorin family of proteins, which are known for their role in cell-cell signaling. SEMA4F is a 21-kDa protein that is expressed in the liver, heart, and pancreas, among other tissues.

SEMA4F is involved in a variety of physiological processes in the body, including cell signaling, angiogenesis, and inflammation. It is a key regulator of the blood-brain barrier, which is responsible for controlling the movement of substances into and out of the brain. SEMA4F is also involved in the development and maintenance of blood vessels, including the vasculature of the pancreas.

SEMA4F has also been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Its role in these diseases has led to the potential use of SEMA4F as a drug target or biomarker.

One of the most promising aspects of SEMA4F is its potential as a drug target. SEMA4F has been shown to play a role in a variety of signaling pathways, including the Wnt/FGF signaling pathway. This pathway is involved in the development and maintenance of tissues, including blood vessels. SEMA4F is a key regulator of this pathway, and its dysfunction has been implicated in the development of various diseases.

SEMA4F has also been shown to play a role in the FGF signaling pathway, which is involved in the development and maintenance of tissues, including muscles and bones. Its dysfunction has also been implicated in the development of various diseases.

In addition to its role in signaling pathways, SEMA4F has also been shown to play a role in the development and maintenance of the blood-brain barrier. The blood-brain barrier is a specialized barrier that separates the brain from the surrounding blood vessels. SEMA4F is involved in the development and maintenance of this barrier, and its dysfunction has been implicated in the development of various neurological disorders.

SEMA4F has also been shown to play a role in the development and progression of cancer. Its dysfunction has been implicated in the development of various types of cancer, including neuroendocrine, breast, and colon cancer.

In conclusion, SEMA4F is a protein that is involved in a variety of physiological processes in the body. Its dysfunction has been implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Its potential as a drug target or biomarker makes it an attractive target for research into the treatment of these diseases. Further studies are needed to fully understand the role of SEMA4F in these diseases and to develop effective treatments.

Protein Name: Ssemaphorin 4F

Functions: Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity). Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal ganglion-cell axons (By similarity)

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