SEMA4A: A Potential Drug Target and Biomarker (G64218)

Target Name: SEMA4A

NCBI ID: G64218

SEMA4A: A Potential Drug Target and Biomarker

SEMA4A, short for small subunit alpha-globin, is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a subunit of the alpha-globin gene, which encodes the protein alpha-globin, a protein that is responsible for carrying oxygen from the lungs to the rest of the body.

SEMA4A has been identified as a potential drug target due to its involvement in the regulation of cell growth and differentiation. It has been shown to play a role in the development and maintenance of neural stem cells, which are important for the development and maintenance of the nervous system.

Additionally, SEMA4A has also been shown to be involved in the regulation of blood cell development and function, which could make it a potential target for treatments for diseases such as cancer and osteoporosis.

SEMA4A is also a biomarker, which can be used to diagnose and monitor a variety of diseases. For example, SEMA4A has been shown to be elevated in the blood of patients with multiple sclerosis, a progressive neurodegenerative disease.

Furthermore, SEMA4A has also been shown to be elevated in the blood of patients with heart failure, a condition in which the heart is not able to pump enough blood to meet the body's needs.

In conclusion, SEMA4A is a protein that has been shown to play a role in a variety of processes in the body, including the regulation of cell growth and differentiation, blood cell development and function, and the regulation of oxygen transport. As a result, it is a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of SEMA4A in the body and its potential as a drug.

Protein Name: Semaphorin 4A

Functions: Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity)

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