SEC14L5: A Protein Targeted for Cancer and Diabetes (G9717)

Target Name: SEC14L5

NCBI ID: G9717

SEC14L5: A Protein Targeted for Cancer and Diabetes

SEC14L5 (Sec14L5_HUMAN), also known as human secreted growth factor 14 (HGF14), is a protein that plays a crucial role in cell signaling and growth regulation. It is a member of the TGF-β (transforming growth factor beta) family, which is known for their ability to promote cell growth, differentiation, and survival.

SEC14L5 is a 14-kDa protein that is expressed in a variety of tissues throughout the body, including the liver, pancreas, and blood vessels. It is primarily localized to the cytoplasm of cells and can also be found in the cell nucleus.

One of the most significant functions of SEC14L5 is its role in cell signaling. It is a potent negative regulator of the TGF-β signaling pathway, which is responsible for promoting cell growth and differentiation. By inhibiting the activity of the TGF-β transcription factor , SEC14L5 helps to prevent excessive cell growth and ensure that cells maintain their proper size and shape.

In addition to its role in cell signaling, SEC14L5 is also a potential drug target. Its unique structure and its ability to interact with various signaling pathways make it an attractive target for small molecules. Several studies have identified potential small molecules that can inhibit the activity of SEC14L5 and have shown promise in clinical trials for treating various diseases, including cancer, diabetes, and cardiovascular disease.

One of the most promising potential small molecules for SEC14L5 inhibition is a compound called U012678, which is a inhibitor of the TGF-β signaling pathway. U012678 has been shown to inhibit the activity of SEC14L5 in cell experiments and has been tested in clinical trials for the treatment of various diseases, including cancer and diabetes.

Another small molecule that has been shown to inhibit the activity of SEC14L5 is called Y276225, which is a tyrosine inhibitor. Y276225 has also been shown to inhibit the activity of SEC14L5 in cell experiments and has been tested in clinical trials for the treatment of various diseases , including cancer.

In conclusion, SEC14L5 is a protein that plays a crucial role in cell signaling and growth regulation. Its unique structure and its ability to interact with various signaling pathways make it an attractive target for small molecules. Several studies have identified potential small molecules that can inhibit the activity of SEC14L5 and have shown promise in clinical trials for the treatment of various diseases. Further research is needed to fully understand the role of SEC14L5 in cell signaling and to develop safe and effective small molecules for its inhibition.

Protein Name: SEC14 Like Lipid Binding 5

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