SEC11C: A Protein Involved in Cell Signaling, Angiogenesis and Inflammation

Target Name: SEC11C

NCBI ID: G90701

SEC11C: A Protein Involved in Cell Signaling, Angiogenesis and Inflammation

SEC11C (SEC11-like 3) is a protein that is expressed in a variety of cell types, including epithelial cells, neurons, and immune cells. It is characterized by a highly conserved catalytic core and a unique N-terminus that is composed of a 21 amino acid sequence known as SEC11.

The catalytic core of SEC11C is a secretory protein that is involved in the regulation of various cellular processes, including cell signaling, angiogenesis, and inflammation. It is expressed in a variety of tissues and cell types, including the epithelial tissue, the neuron, and the immune cell.

One of the unique features of SEC11C is its N-terminus, which is composed of a 21 amino acid sequence known as SEC11. This sequence is highly conserved across various species, including humans, and is involved in the formation of a distinct N-terminal region that is involved in various cellular processes.

The N-terminus of SEC11C is involved in the formation of a complex with other proteins, including the transcription factor NF-kappa-B. This interaction between SEC11C and NF-kappa-B is important for the regulation of various cellular processes, including cell signaling, angiogenesis, and inflammation.

In addition to its role in cell signaling and angiogenesis, SEC11C is also involved in the regulation of inflammation. It is a known regulator of the immune response and has been shown to play a role in the regulation of inflammation.

As a drug target, SEC11C is a promising target for the development of new treatments for various diseases, including cancer, cardiovascular disease, and neurodegenerative diseases. The unique characterization of SEC11C, as a protein that is involved in the regulation of various cellular processes, makes it an attractive target for the development of new drugs that can modulate these processes.

In conclusion, SEC11C is a protein that is characterized by a highly conserved catalytic core and a unique N-terminus. It is expressed in a variety of cell types and is involved in the regulation of various cellular processes, including cell signaling, angiogenesis, and inflammation. As a drug target, SEC11C is a promising target for the development of new treatments for various diseases. Further research is needed to fully understand the role of SEC11C in cellular processes and to develop new treatments based on this protein.

Protein Name: SEC11 Homolog C, Signal Peptidase Complex Subunit

Functions: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (PubMed:34388369)

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