Understanding GPR83: A G Protein-coupled Receptor and Its Potential Drug Target Status

Target Name: GPR83

NCBI ID: G10888

Understanding GPR83: A G Protein-coupled Receptor and Its Potential Drug Target Status

GPR83 (G protein-coupled receptor 83) is a G protein-coupled receptor that is expressed in many tissues and cells in the body. It is involved in various physiological processes, including sensory perception, neurotransmitter signaling, and hormone regulation. GPR83 has also been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders.

GPR83 is a member of the G protein-coupled receptor family, which is a large superfamily of transmembrane proteins that play a key role in cellular signaling. The G protein-coupled receptor family consists of over 700 different genes and is involved in a wide range of physiological processes, including sensory perception, neurotransmitter signaling, and hormone regulation.

GPR83 is a type of G protein-coupled receptor that is expressed in many tissues and cells in the body. It is located on the surface of many different cell types, including neurons, muscle cells, and epithelial cells. GPR83 is involved in various physiological processes, including sensory perception, neurotransmitter signaling, and hormone regulation.

One of the unique features of GPR83 is its structure. GPR83 has a long extracellular domain that is involved in its signaling properties. This domain includes a region of tryptophan, which is known for its role in G protein-coupled receptor signaling. Additionally, GPR83 has a short intracellular domain that is involved in its internal signaling mechanisms.

GPR83 is involved in a wide range of physiological processes in the body. For example, GPR83 is involved in the sense of touch and in the regulation of pain. It is also involved in the signaling of neurotransmitters, such as dopamine and serotonin, which are involved in mood, emotion, and other physiological processes. Additionally, GPR83 is involved in the regulation of hormone levels, such as the production of insulin by the pancreas.

GPR83 has also been identified as a potential drug target and a biomarker for various diseases. For example, GPR83 has been shown to be involved in the development and progression of cancer, including breast cancer. Additionally, GPR83 has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. It is also involved in the development of psychiatric disorders, such as depression and anxiety.

In conclusion, GPR83 is a G protein-coupled receptor that is involved in various physiological processes in the body. It is a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. Further research is needed to fully understand the role of GPR83 in these processes and to develop effective treatments for these diseases.

Protein Name: G Protein-coupled Receptor 83

Functions: G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN (PubMed:27117253). Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity)

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