Unlocking the Potential of Ribosomal Protein S4 Y-linked 2 (RPS4Y2) as a Drug Target and Biomarker

Target Name: RPS4Y2

NCBI ID: G140032

Unlocking the Potential of Ribosomal Protein S4 Y-linked 2 (RPS4Y2) as a Drug Target and Biomarker

Introduction

Ribosomal protein S4 Y-linked 2 (RPS4Y2) is a protein that plays a crucial role in the regulation of gene expression and cell biology. RPS4Y2 is a key regulator of the small subunit ribosomal A (ssA) protein, which is a key component of the ribosome, the site of protein synthesis. The regulation of RPS4Y2 function is essential for proper cell growth, development, and function. However, its regulation is often disrupted in various diseases, including cancer, neurodegenerative diseases, and metabolic disorders. As a result , targeting RPS4Y2 has become an attractive therapeutic strategy to develop new treatments for these diseases.

Drugs that target RPS4Y2 have the potential to modulate its activity and improve the efficacy of existing treatments. This is because RPS4Y2 is a protein that is expressed in most tissues and cells, making it an attractive target for small molecules and other therapeutic agents. Additionally, Its expression is often modulated by various cellular stressors, including reactive oxygen species (ROS), which can act as a natural intracellular stress indicator. This makes RPS4Y2 an attractive target for therapeutic interventions that aim to reduce cellular stress and improve cellular function.

Expression and localization of RPS4Y2

RPS4Y2 is a member of the S4 family of ribosomal proteins, which are involved in the regulation of gene expression and protein synthesis. The S4 family includes several subfamilies, including S4A, S4B, S4C, and S4D. RPS4Y2 belongs to the S4B subfamily, which is responsible for the regulation of the small subunit ribosomal A protein (ssA).

RPS4Y2 is expressed in most tissues and cells and is primarily localized to the endoplasmic reticulum (ER) and the cytoplasm. It is highly stable and has a relatively long half-life of approximately 18 hours, which allows it to be targeted by small molecules and other therapeutic agents. Additionally, RPS4Y2 is a good predictor of cell viability, which can be used to selectively target RPS4Y2-expressing cells that are more susceptible to therapeutic intervention.

Function and regulation of RPS4Y2

RPS4Y2 is involved in the regulation of gene expression and protein synthesis by binding to specific DNA sequences and interacting with various cellular factors. One of its well-known functions is its role in the regulation of cell growth and differentiation. RPS4Y2 has been shown to play a negative role in the regulation of cell cycle progression and the maintenance of cellular stemness. It has been shown to promote the G1/S transition, which is a critical step in cell cycle progression, and to inhibit the G0/G1 transition, which is necessary for cell growth and differentiation.

In addition to its role in cell growth and differentiation, RPS4Y2 is also involved in the regulation of protein synthesis. It has been shown to function as a negative regulator of the translation of ribosomal proteins (RPNs), which are involved in the production of proteins from mRNA. RPS4Y2 has been shown to interact with several RPNs, including RPS4Y2-associated protein (RAP), which is involved in the translation of RPNs. Additionally, RPS4Y2 has been shown to interact with the protein hypoxia-inducible factor (HIF), which is involved in the regulation of cellular stress and is a potential therapeutic target for

Protein Name: Ribosomal Protein S4 Y-linked 2

More Common Targets