EIF4G1: A Drug Target / Disease Biomarker (G1981)

Target Name: EIF4G1

NCBI ID: G1981

EIF4G1: A Drug Target / Disease Biomarker

EIF4G1, also known as EIF4G1-ASP, is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key regulator of the homeostasis of cells, and is involved in the regulation of inflammation, autophagy, and cellular signaling pathways.

Recent studies have identified EIF4G1 as a potential drug target or biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is because of its involvement in the regulation of cellular processes that are often disrupted in these conditions, as well as its unique structure and expression pattern.

One of the key reasons for the potential of EIF4G1 as a drug target is its location in the cell. EIF4G1 is a protein that is expressed in the brain, and is highly co-expressed in this tissue. This suggests that it is involved in the regulation of processes that are specific to the brain, and may be a useful target for drugs that target brain-related diseases.

In addition, EIF4G1 is involved in the regulation of cellular signaling pathways that are important in the development and progression of many diseases. For example, it has been shown to be involved in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Another potential reason for the interest in EIF4G1 as a drug target is its unique structure. EIF4G1 is a transmembrane protein that is composed of four transmembrane domains and a cytoplasmic tail. This unique structure suggests that it may be able to interact with other proteins that are also transmembrane, and may be a useful target for drugs that target such interactions.

Finally, EIF4G1 has been shown to be involved in the regulation of cellular processes that are important in many diseases, including cancer. For example, it has been shown to be involved in the regulation of cell division and the detoxification of environmental toxins, and may be a useful target for drugs that target these processes in cancer cells.

In conclusion, EIF4G1 is a protein that is expressed in various tissues of the body and is involved in the regulation of cellular processes that are important in the development and progression of many diseases. Its unique structure and location in the cell make it a potential target for drugs that target brain-related diseases, and its involvement in the regulation of cellular signaling pathways and processes important in the development and progression of cancer make it a promising biomarker for this disease. Further research is needed to fully understand the role of EIF4G1 as a drug target or biomarker, and to develop effective treatments for the diseases in which it is involved.

Protein Name: Eukaryotic Translation Initiation Factor 4 Gamma 1

Functions: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139)

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